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    SLC6A16 solute carrier family 6 member 16 [ Homo sapiens (human) ]

    Gene ID: 28968, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC6A16provided by HGNC
    Official Full Name
    solute carrier family 6 member 16provided by HGNC
    Primary source
    HGNC:HGNC:13622
    See related
    Ensembl:ENSG00000063127 MIM:607972; AllianceGenome:HGNC:13622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NT5; NTT5
    Summary
    SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 36.6) and ovary (RPKM 1.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC6A16 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49289638..49340330, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52287044..52337761, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49792895..49828448, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985340 Neighboring gene solute carrier family 6 member 21, pseudogene Neighboring gene SUMO1 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14930 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49816848-49817070 Neighboring gene microRNA 4324 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14931 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49830555-49830706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49842721-49843696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14936 Neighboring gene CD37 molecule Neighboring gene TEA domain transcription factor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49863002-49863502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49864048-49864757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49864758-49865466 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neurotransmitter transmembrane transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
    Names
    CTC-301O7.4
    solute carrier family 6 (neurotransmitter transporter), member 16

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014037.3NP_054756.2  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

      See identical proteins and their annotated locations for NP_054756.2

      Status: VALIDATED

      Source sequence(s)
      AL136856, AW451672, BG772801
      Consensus CDS
      CCDS42590.1
      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
      Related
      ENSP00000338627.3, ENST00000335875.9
      Conserved Domains (1) summary
      cd11502
      Location:103673
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49289638..49340330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438703.1XP_047294659.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X3

    2. XM_047438702.1XP_047294658.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1

    3. XM_011526860.3XP_011525162.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X4

      Conserved Domains (1) summary
      cd11502
      Location:125695
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
    4. XM_047438701.1XP_047294657.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1

    5. XM_006723168.4XP_006723231.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      See identical proteins and their annotated locations for XP_006723231.1

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
      Conserved Domains (1) summary
      cd11502
      Location:103673
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
    6. XM_047438704.1XP_047294660.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6

    7. XM_011526859.4XP_011525161.3  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X2

    8. XM_024451472.2XP_024307240.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
      Conserved Domains (1) summary
      cd11502
      Location:103673
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
    9. XM_005258820.4XP_005258877.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      See identical proteins and their annotated locations for XP_005258877.1

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
      Conserved Domains (1) summary
      cd11502
      Location:103673
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
    10. XM_011526861.4XP_011525163.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6

      Conserved Domains (1) summary
      cd11502
      Location:1526
      SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52287044..52337761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320738.1XP_054176713.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X3

    2. XM_054320739.1XP_054176714.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X4

    3. XM_054320741.1XP_054176716.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
    4. XM_054320744.1XP_054176719.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6

    5. XM_054320737.1XP_054176712.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X2

    6. XM_054320742.1XP_054176717.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
    7. XM_054320740.1XP_054176715.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

      UniProtKB/Swiss-Prot
      Q8IYV4, Q9GZN6, Q9Y5I9
    8. XM_054320743.1XP_054176718.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6