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    LZTS3 leucine zipper tumor suppressor family member 3 [ Homo sapiens (human) ]

    Gene ID: 9762, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LZTS3provided by HGNC
    Official Full Name
    leucine zipper tumor suppressor family member 3provided by HGNC
    Primary source
    HGNC:HGNC:30139
    See related
    Ensembl:ENSG00000088899 MIM:610484; AllianceGenome:HGNC:30139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PROSAPIP1
    Summary
    Predicted to enable PDZ domain binding activity. Predicted to be involved in protein homooligomerization; regulation of dendritic spine morphogenesis; and regulation of postsynapse assembly. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine and glutamatergic synapse. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 17.2), kidney (RPKM 9.1) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LZTS3 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3162617..3173549, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3193522..3204462, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3143263..3154195, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12614 Neighboring gene uncharacterized LOC107985414 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:3163335-3163502 Neighboring gene DDRGK domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:3183418-3184016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17476 Neighboring gene inosine triphosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. In silico characterization of LZTS3, a potential tumor suppressor. Teufel A, et al. Oncol Rep, 2005 Aug. PMID 16012743
    2. Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275. Feng J, et al. Bioengineered, 2021 Dec. PMID 33315502, Free PMC Article
    3. Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies. Grabrucker AM, et al. Trends Cell Biol, 2011 Oct. PMID 21840719
    4. LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton. Gu X, et al. Arch Med Res, 2023 Nov. PMID 37806182
    5. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. Wendholt D, et al. J Biol Chem, 2006 May 12. PMID 16522626

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton.
      Title: LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton.
    2. Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275.
      Title: Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275.
    3. We thus propose a model where ProSAP/Shank proteins are in the center of a postsynaptic signaling pathway that is disrupted in several neuropsychiatric disorders.
      Title: Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0552, RP5-1187M17.10

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 3
    Names
    ProSAP/Shank-interacting protein 1
    leucine zipper, putative tumor suppressor family member 3
    proline rich synapse associated protein interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282533.2 → NP_001269462.1  leucine zipper putative tumor suppressor 3 isoform 2

      See identical proteins and their annotated locations for NP_001269462.1

      Status: VALIDATED

      Source sequence(s)
      AB011124, AL121891, BC038860, BU684906, HY126776
      Consensus CDS
      CCDS63218.1
      UniProtKB/Swiss-Prot
      O60299
      Related
      ENSP00000353496.3, ENST00000360342.7
      Conserved Domains (2) summary
      pfam06818
      Location:392 → 591
      Fez1; Fez1
      cl25742
      Location:322 → 451
      ERM; Ezrin/radixin/moesin family

    2. NM_001365618.1 → NP_001352547.1  leucine zipper putative tumor suppressor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Consensus CDS
      CCDS13049.1
      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8
      Related
      ENSP00000338166.6, ENST00000337576.7
      Conserved Domains (2) summary
      COG1196
      Location:318 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1

    3. NM_001367609.1 → NP_001354538.1  leucine zipper putative tumor suppressor 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Conserved Domains (2) summary
      COG1196
      Location:348 → 545
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:468 → 668
      Fez1

    4. NM_001388189.1 → NP_001375118.1  leucine zipper putative tumor suppressor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Consensus CDS
      CCDS13049.1
      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8
      Conserved Domains (2) summary
      COG1196
      Location:318 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1

    5. NM_001388190.1 → NP_001375119.1  leucine zipper putative tumor suppressor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Consensus CDS
      CCDS13049.1
      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8
      Conserved Domains (2) summary
      COG1196
      Location:318 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1

    6. NM_001388191.1 → NP_001375120.1  leucine zipper putative tumor suppressor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Consensus CDS
      CCDS13049.1
      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8
      Related
      ENSP00000332123.3, ENST00000329152.7
      Conserved Domains (2) summary
      COG1196
      Location:318 → 515
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1

    7. NM_001388192.1 → NP_001375121.1  leucine zipper putative tumor suppressor 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Conserved Domains (2) summary
      COG1196
      Location:348 → 524
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:451 → 647
      Fez1

    8. NM_001388193.1 → NP_001375122.1  leucine zipper putative tumor suppressor 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL121891
      Conserved Domains (2) summary
      COG1196
      Location:318 → 494
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:421 → 617
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      3162617..3173549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529408.4 → XP_011527710.1  leucine zipper putative tumor suppressor 3 isoform X1

      See identical proteins and their annotated locations for XP_011527710.1

      Conserved Domains (2) summary
      COG1196
      Location:348 → 545
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:468 → 668
      Fez1

    2. XM_011529409.4 → XP_011527711.1  leucine zipper putative tumor suppressor 3 isoform X1

      See identical proteins and their annotated locations for XP_011527711.1

      Conserved Domains (2) summary
      COG1196
      Location:348 → 545
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:468 → 668
      Fez1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      3193522..3204462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324275.1 → XP_054180250.1  leucine zipper putative tumor suppressor 3 isoform X2

    2. XM_054324273.1 → XP_054180248.1  leucine zipper putative tumor suppressor 3 isoform X1

    3. XM_054324277.1 → XP_054180252.1  leucine zipper putative tumor suppressor 3 isoform X3

      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8

    4. XM_054324276.1 → XP_054180251.1  leucine zipper putative tumor suppressor 3 isoform X3

      UniProtKB/Swiss-Prot
      A2A2Q7, D3DVX6, O60299, Q8IXX8

    5. XM_054324274.1 → XP_054180249.1  leucine zipper putative tumor suppressor 3 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014731.2: Suppressed sequence

      Description
      NM_014731.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60299.1 GenPept UniProtKB/Swiss-Prot:O60299

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