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    STPG2 sperm tail PG-rich repeat containing 2 [ Homo sapiens (human) ]

    Gene ID: 285555, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STPG2provided by HGNC
    Official Full Name
    sperm tail PG-rich repeat containing 2provided by HGNC
    Primary source
    HGNC:HGNC:28712
    See related
    Ensembl:ENSG00000163116 AllianceGenome:HGNC:28712
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C4orf37
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See STPG2 in Genome Data Viewer
    Location:
    4q22.3-q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (97441249..98143476, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (100756071..101458472, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (98480023..99064627, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:98045039-98045539 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:98060958-98062157 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:98062416-98062997 Neighboring gene uncharacterized LOC124900737 Neighboring gene STPG2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21731 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:98508983-98510182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:98554318-98554902 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:98554903-98555487 Neighboring gene Sharpr-MPRA regulatory region 6700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:98699102-98699602 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:98824980-98825528 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:98845219-98845420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:98944941-98945440 Neighboring gene crystallin zeta pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:99031922-99032747 Neighboring gene ribosomal protein L5 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21732 Neighboring gene uncharacterized LOC105377340 Neighboring gene deoxyuridine triphosphatase pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:99125201-99125922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:99181827-99182389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15577 Neighboring gene Rap1 GTPase-GDP dissociation stimulator 1 Neighboring gene uncharacterized LOC124900919

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exceptional complex chromosomal rearrangement and microdeletions at the 4q22.3q23 and 14q31.1q31.3 regions in a patient with azoospermia. Yakut S, et al. Gene, 2013 Jan 1. PMID 23031811
    2. Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system. Jiang J, et al. Front Genet, 2013. PMID 24009623, Free PMC Article
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
    5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46496

    General protein information

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    Preferred Names
    sperm-tail PG-rich repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174952.3 → NP_777612.1  sperm-tail PG-rich repeat-containing protein 2

      See identical proteins and their annotated locations for NP_777612.1

      Status: VALIDATED

      Source sequence(s)
      AC019077, AC034154, BC036870
      Consensus CDS
      CCDS3645.1
      UniProtKB/Swiss-Prot
      Q8N412
      Related
      ENSP00000295268.3, ENST00000295268.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      97441249..98143476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450118.1 → XP_047306074.1  sperm-tail PG-rich repeat-containing protein 2 isoform X3

    2. XM_017008049.3 → XP_016863538.1  sperm-tail PG-rich repeat-containing protein 2 isoform X2

    3. XM_011531886.4 → XP_011530188.1  sperm-tail PG-rich repeat-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011530188.1

    4. XM_017008051.3 → XP_016863540.1  sperm-tail PG-rich repeat-containing protein 2 isoform X6

    5. XM_047450119.1 → XP_047306075.1  sperm-tail PG-rich repeat-containing protein 2 isoform X4

    6. XM_047450120.1 → XP_047306076.1  sperm-tail PG-rich repeat-containing protein 2 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      100756071..101458472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349785.1 → XP_054205760.1  sperm-tail PG-rich repeat-containing protein 2 isoform X1

    2. XM_054349787.1 → XP_054205762.1  sperm-tail PG-rich repeat-containing protein 2 isoform X2

    3. XM_054349788.1 → XP_054205763.1  sperm-tail PG-rich repeat-containing protein 2 isoform X3

    4. XM_054349791.1 → XP_054205766.1  sperm-tail PG-rich repeat-containing protein 2 isoform X6

    5. XM_054349789.1 → XP_054205764.1  sperm-tail PG-rich repeat-containing protein 2 isoform X4

    6. XM_054349790.1 → XP_054205765.1  sperm-tail PG-rich repeat-containing protein 2 isoform X5

    7. XM_054349786.1 → XP_054205761.1  sperm-tail PG-rich repeat-containing protein 2 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N412.1 GenPept UniProtKB/Swiss-Prot:Q8N412

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