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    IQGAP2 IQ motif containing GTPase activating protein 2 [ Homo sapiens (human) ]

    Gene ID: 10788, updated on 27-Nov-2024

    Summary

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    Official Symbol
    IQGAP2provided by HGNC
    Official Full Name
    IQ motif containing GTPase activating protein 2provided by HGNC
    Primary source
    HGNC:HGNC:6111
    See related
    Ensembl:ENSG00000145703 MIM:605401; AllianceGenome:HGNC:6111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
    Expression
    Broad expression in liver (RPKM 36.3), duodenum (RPKM 28.2) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IQGAP2 in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76403285..76708132)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (76885042..77189993)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (75699110..76003957)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2C Neighboring gene uncharacterized LOC105379042 Neighboring gene NANOG hESC enhancer GRCh37_chr5:75592019-75592901 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:75590840-75592039 Neighboring gene GATA motif-containing MPRA enhancer 83 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:75621257-75621756 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:75631008-75631638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:75632271-75632901 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:75633873-75634098 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:75635379-75636148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22689 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:75652737-75653716 Neighboring gene Sharpr-MPRA regulatory region 10118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:75690574-75691074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:75691075-75691575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:75699075-75699575 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:75767824-75769023 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:75794074-75794996 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:75794997-75795918 Neighboring gene sulfiredoxin 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22690 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:75852604-75853098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22693 Neighboring gene uncharacterized LOC101929109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22694 Neighboring gene Sharpr-MPRA regulatory region 1022 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76013800-76014300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76014301-76014801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16107 Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene coagulation factor II thrombin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL. Tang T, et al. BMC Cancer, 2021 May 25. PMID 34034707, Free PMC Article
    2. Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. Deng Z, et al. Int J Oncol, 2016 Jan. PMID 26549344
    3. IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway. Brisac C, et al. J Hepatol, 2016 Nov. PMID 27401546, Free PMC Article
    4. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Jin SH, et al. Int J Cancer, 2008 Mar 1. PMID 17957782
    5. Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. Kumar D, et al. Cell Death Dis, 2021 Apr 12. PMID 33846302, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.
      Title: Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.
    2. IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
      Title: IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
    3. Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.
      Title: Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status.
    4. Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjogren's syndrome.
      Title: Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome.
    5. IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
      Title: IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity.
    6. Data suggest that CDC42 binding to Ex-domain of IQGAP2 releases Ex-domain at C-terminal region of GRD2 domain, facilitating IQGAP2 dimerization; this promotes allosteric changes in ras GTPase-activating protein binding site providing binding site for second CDC42; RAC1 binds only to apo-IQGAP2. (IQGAP2 = IQ motif containing GTPase activating protein-2; CDC42 = GTP-binding protein CDC42; RAC1 = Rac family small GTPase-1)
      Title: Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
    7. IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability
      Title: Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.
    8. The structural basis for Cdc42-induced dimerization of IQGAP1 and IQGAP2 has been uncovered.
      Title: The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.
    9. The most frequently identified and connected to preterm birth genes in the exome library were IGF1, ATM and IQGAP2.
      Title: Targeted Sequencing and Meta-Analysis of Preterm Birth.
    10. IQGAP2 TagSNP rs457717 (A/G) was not associated with Age-Related Hearing impairment in Han male Chinese population.
      Title: The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study for age-related hearing impairment in the Saami.
    EBI GWAS Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic actomyosin contractile ring assembly actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in thrombin-activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053128.2 RefSeqGene

      Range
      5002..309849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001285460.2 → NP_001272389.2  ras GTPase-activating-like protein IQGAP2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC025188, AC026706, AC026725
      Consensus CDS
      CCDS75262.1
      UniProtKB/TrEMBL
      B7Z7U6, F5H7S7
      Related
      ENSP00000442313.2, ENST00000379730.7
      Conserved Domains (4) summary
      smart00015
      Location:639 → 660
      IQ; Calmodulin-binding motif
      COG5261
      Location:734 → 1525
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cl00030
      Location:1 → 116
      CH_SF; calponin homology (CH) domain superfamily
      cl02569
      Location:866 → 1224
      RasGAP; Ras GTPase Activating Domain

    2. NM_001285461.2 → NP_001272390.2  ras GTPase-activating-like protein IQGAP2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has several differences compared to variant 1, including an alternate 5' terminal exon, use of an alternate translation initiation codon and lacking an in-frame coding exon. The resulting shorter isoform (3) has a novel N-terminus and lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC025188, AC026706, AC026725
      Consensus CDS
      CCDS68897.1
      UniProtKB/TrEMBL
      Q59HA3
      Related
      ENSP00000379535.3, ENST00000396234.7
      Conserved Domains (3) summary
      smart00456
      Location:153 → 180
      WW; Domain with 2 conserved Trp (W) residues
      cd05131
      Location:412 → 770
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:280 → 1071
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

    3. NM_001285462.2 → NP_001272391.2  ras GTPase-activating-like protein IQGAP2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has several differences compared to variant 1, including an alternate 5' terminal exon, use of an alternate translation initiation codon and lacking an in-frame coding exon. The resulting shorter isoform (4) has a novel N-terminus and lacks an internal protein segment compared to isoform 1.
      Source sequence(s)
      AC025188, AC026706, AC026725
      Consensus CDS
      CCDS68898.1
      UniProtKB/TrEMBL
      Q59HA3
      Related
      ENSP00000426027.1, ENST00000502745.5
      Conserved Domains (3) summary
      smart00456
      Location:153 → 180
      WW; Domain with 2 conserved Trp (W) residues
      cd05131
      Location:412 → 770
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5261
      Location:280 → 1071
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

    4. NM_006633.5 → NP_006624.3  ras GTPase-activating-like protein IQGAP2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC025188, AC026706, AC026725, AC093251, AC112173
      Consensus CDS
      CCDS34188.1
      UniProtKB/Swiss-Prot
      A8K4V1, B7Z8A4, J3KR91, Q13576
      UniProtKB/TrEMBL
      B7Z7U6
      Related
      ENSP00000274364.6, ENST00000274364.11
      Conserved Domains (4) summary
      smart00015
      Location:689 → 710
      IQ; Calmodulin-binding motif
      COG5261
      Location:784 → 1575
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd21275
      Location:11 → 166
      CH_IQGAP2; calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2
      cl02569
      Location:916 → 1274
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      76403285..76708132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008960.2 → XP_016864449.1  ras GTPase-activating-like protein IQGAP2 isoform X5

      UniProtKB/TrEMBL
      B7Z7U6

    2. XM_047416641.1 → XP_047272597.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    3. XM_005248410.4 → XP_005248467.1  ras GTPase-activating-like protein IQGAP2 isoform X3

      UniProtKB/TrEMBL
      B7Z7U6
      Conserved Domains (3) summary
      smart00015
      Location:662 → 683
      IQ; Calmodulin-binding motif
      cd05131
      Location:889 → 1247
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      cl27227
      Location:757 → 1548
      RasGAP_C; RasGAP C-terminus

    4. XM_024454336.2 → XP_024310104.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      UniProtKB/TrEMBL
      B7Z7U6
      Conserved Domains (3) summary
      smart00015
      Location:687 → 708
      IQ; Calmodulin-binding motif
      cd05131
      Location:914 → 1272
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      cl27227
      Location:782 → 1573
      RasGAP_C; RasGAP C-terminus

    5. XM_047416643.1 → XP_047272599.1  ras GTPase-activating-like protein IQGAP2 isoform X4

      UniProtKB/TrEMBL
      F5H7S7

    6. XM_047416642.1 → XP_047272598.1  ras GTPase-activating-like protein IQGAP2 isoform X4

      UniProtKB/TrEMBL
      F5H7S7

    7. XM_005248414.3 → XP_005248471.1  ras GTPase-activating-like protein IQGAP2 isoform X7

      UniProtKB/TrEMBL
      Q59HA3
      Conserved Domains (4) summary
      smart00015
      Location:242 → 263
      IQ; Calmodulin-binding motif
      cd05131
      Location:469 → 827
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:458 → 787
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:920 → 1051
      RasGAP_C; RasGAP C-terminus

    8. XM_011543108.3 → XP_011541410.1  ras GTPase-activating-like protein IQGAP2 isoform X6

      UniProtKB/TrEMBL
      Q59HA3
      Conserved Domains (4) summary
      smart00015
      Location:242 → 263
      IQ; Calmodulin-binding motif
      cd05131
      Location:469 → 827
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      smart00323
      Location:458 → 787
      RasGAP; GTPase-activator protein for Ras-like GTPases
      pfam03836
      Location:920 → 1051
      RasGAP_C; RasGAP C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      76885042..77189993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351462.1 → XP_054207437.1  ras GTPase-activating-like protein IQGAP2 isoform X5

    2. XM_054351458.1 → XP_054207433.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    3. XM_054351460.1 → XP_054207435.1  ras GTPase-activating-like protein IQGAP2 isoform X3

    4. XM_054351459.1 → XP_054207434.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    5. XM_054351461.1 → XP_054207436.1  ras GTPase-activating-like protein IQGAP2 isoform X4

    6. XM_054351464.1 → XP_054207439.1  ras GTPase-activating-like protein IQGAP2 isoform X7

    7. XM_054351463.1 → XP_054207438.1  ras GTPase-activating-like protein IQGAP2 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13576.4 GenPept UniProtKB/Swiss-Prot:Q13576

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