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    PHF20L1 PHD finger protein 20 like 1 [ Homo sapiens (human) ]

    Gene ID: 51105, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PHF20L1provided by HGNC
    Official Full Name
    PHD finger protein 20 like 1provided by HGNC
    Primary source
    HGNC:HGNC:24280
    See related
    Ensembl:ENSG00000129292 MIM:620050; AllianceGenome:HGNC:24280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    URLC1; CGI-72; TDRD20B
    Summary
    Enables methylation-dependent protein binding activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 4.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PHF20L1 in Genome Data Viewer
    Location:
    8q24.22
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (132775388..132848807)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (133898574..133971990)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (133787634..133861052)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 11 Neighboring gene Helicobacter pylori responsive 1 Neighboring gene uncharacterized LOC105375767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:133699646-133700172 Neighboring gene transmembrane protein 71 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:133787363-133787864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:133894667-133895168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:133895169-133895668 Neighboring gene thyroglobulin Neighboring gene uncharacterized LOC105375768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27992 Neighboring gene ribosomal protein L21 pseudogene 78

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts. Francois AK, et al. mBio, 2024 Apr 10. PMID 38411116, Free PMC Article
    2. An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer. Jiang Y, et al. Mol Oncol, 2016 Feb. PMID 26588862, Free PMC Article
    3. PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1. Zhu QC, et al. Biol Chem, 2022 Sep 27. PMID 35357096
    4. Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein. Carr SM, et al. Cell Death Differ, 2017 Dec. PMID 28841214, Free PMC Article
    5. An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer. Sierra-Ramirez JA, et al. Adv Clin Exp Med, 2021 May. PMID 33847474

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.
      Title: Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.
    2. PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1.
      Title: PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1.
    3. PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis.
      Title: PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis.
    4. An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer.
      Title: An insight into the promoter methylation of PHF20L1 and the gene association with metastasis in breast cancer.
    5. associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by the MLL1/WDR5 complexes
      Title: PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes.
    6. Data suggest that, in human ovarian teratocarcinoma cell line, methylation-dependent proteolysis of SOX2 is controlled by LSD1 and PHF20L1 via regulation of SET7 activity; these data are consistent with previous studies in mouse primary stem cells. (SOX2 = SRY-box 2 transcription factor; LSD1 = lysine demethylase-1A; PHF20L1 = PHD finger protein 20 like-1; SET7 = histone-lysine N-methyltransferase SETD7)
      Title: LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.
    7. Authors find that the interplay between PHF20L1 and mono-methyl pRb is important for maintaining the integrity of a pRb-dependent G1-S-phase checkpoint. Results highlight the distinct roles that methyl-lysine readers have in regulating the biological activity of pRb.
      Title: Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.
    8. results demonstrated the oncogenic potential of PHF20L1 and its association with poor prognostic parameters in breast cancer.
      Title: An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.
    9. Malignant brain tumor domain of PHF20L1 reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation.
      Title: Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylation-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 20-like protein 1
    Names
    tudor domain containing 20B
    tudor domain-containing protein PHF20L1
    up-regulated in lung cancer 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277196.2 → NP_001264125.1  PHD finger protein 20-like protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AF228727, AF230666, BC144654, DB498348
      Consensus CDS
      CCDS75791.1
      UniProtKB/TrEMBL
      A0A0A0MQS0
      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:657 → 702
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 291
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:292 → 388
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    2. NM_001362971.2 → NP_001349900.1  PHD finger protein 20-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF228727, AF230666, BC144654, DB498348
      Consensus CDS
      CCDS75791.1
      UniProtKB/TrEMBL
      A0A0A0MQS0
      Related
      ENSP00000220847.8, ENST00000220847.8
      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:657 → 702
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 291
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:292 → 388
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    3. NM_016018.5 → NP_057102.4  PHD finger protein 20-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_057102.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AF230666, AK057961, BC002822, DA196349, DB498348
      Consensus CDS
      CCDS6367.2
      UniProtKB/Swiss-Prot
      A8MW92, A8MZC9, Q86U89, Q86W43, Q96BT0, Q9H702, Q9HBK3, Q9NYR3, Q9Y381
      Related
      ENSP00000378784.2, ENST00000395386.7
      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:683 → 728
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:210 → 317
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:318 → 383
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    4. NM_198513.2 → NP_940915.1  PHD finger protein 20-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_940915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AI913146, AK023711, BC015211, DB498348
      Consensus CDS
      CCDS6368.1
      UniProtKB/TrEMBL
      A8MUE8
      Related
      ENSP00000338269.4, ENST00000337920.8
      Conserved Domains (2) summary
      cd20454
      Location:86 → 144
      Tudor_PHF20L1; Tudor domain found in PHD finger protein 20-like protein 1 (PHF20L1) and similar proteins
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    RNA

    1. NR_156424.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF228727, AF230666, BC144654, DA557575, DB498348

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      132775388..132848807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517075.1 → XP_011515377.1  PHD finger protein 20-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011515377.1

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:688 → 733
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:214 → 322
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:323 → 388
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    2. XM_011517077.1 → XP_011515379.1  PHD finger protein 20-like protein 1 isoform X3

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:687 → 732
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:214 → 321
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:322 → 387
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    3. XM_011517078.1 → XP_011515380.1  PHD finger protein 20-like protein 1 isoform X5

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:684 → 729
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:210 → 318
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:319 → 384
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    4. XM_047421819.1 → XP_047277775.1  PHD finger protein 20-like protein 1 isoform X6

    5. XM_011517079.1 → XP_011515381.1  PHD finger protein 20-like protein 1 isoform X7

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:683 → 728
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:210 → 317
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:318 → 383
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    6. XM_011517080.1 → XP_011515382.1  PHD finger protein 20-like protein 1 isoform X9

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:658 → 703
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 292
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:293 → 358
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    7. XM_047421823.1 → XP_047277779.1  PHD finger protein 20-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F8W9L8
      Related
      ENSP00000378788.2, ENST00000395390.6

    8. XM_011517081.1 → XP_011515383.1  PHD finger protein 20-like protein 1 isoform X11

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:657 → 702
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 291
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:292 → 357
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    9. XM_011517076.1 → XP_011515378.1  PHD finger protein 20-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011515378.1

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:688 → 733
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:214 → 322
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:323 → 388
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    10. XM_047421815.1 → XP_047277771.1  PHD finger protein 20-like protein 1 isoform X2

    11. XM_047421816.1 → XP_047277772.1  PHD finger protein 20-like protein 1 isoform X3

    12. XM_047421817.1 → XP_047277773.1  PHD finger protein 20-like protein 1 isoform X4

    13. XM_047421818.1 → XP_047277774.1  PHD finger protein 20-like protein 1 isoform X5

    14. XM_047421820.1 → XP_047277776.1  PHD finger protein 20-like protein 1 isoform X6

    15. XM_017013509.1 → XP_016868998.1  PHD finger protein 20-like protein 1 isoform X7

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:683 → 728
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:210 → 317
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:318 → 383
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    16. XM_047421821.1 → XP_047277777.1  PHD finger protein 20-like protein 1 isoform X8

      UniProtKB/Swiss-Prot
      A8MW92, A8MZC9, Q86U89, Q86W43, Q96BT0, Q9H702, Q9HBK3, Q9NYR3, Q9Y381
      Related
      ENSP00000482945.1, ENST00000622263.4

    17. XM_017013510.1 → XP_016868999.1  PHD finger protein 20-like protein 1 isoform X9

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:658 → 703
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 292
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:293 → 358
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    18. XM_047421822.1 → XP_047277778.1  PHD finger protein 20-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F8W9L8

    19. XM_017013511.1 → XP_016869000.1  PHD finger protein 20-like protein 1 isoform X11

      Conserved Domains (5) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15633
      Location:657 → 702
      PHD_PHF20L1; PHD finger found in PHD finger protein 20-like protein 1 (P20L1)
      pfam12618
      Location:184 → 291
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:292 → 357
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    20. XM_011517088.1 → XP_011515390.1  PHD finger protein 20-like protein 1 isoform X13

      See identical proteins and their annotated locations for XP_011515390.1

      Conserved Domains (4) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam12618
      Location:214 → 322
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:323 → 388
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    21. XM_017013516.1 → XP_016869005.1  PHD finger protein 20-like protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A8K9A6
      Related
      ENST00000315808.14
      Conserved Domains (4) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam12618
      Location:210 → 317
      DUF3776; Protein of unknown function (DUF3776)
      pfam16660
      Location:318 → 383
      PHD20L1_u1; PHD finger protein 20-like protein 1
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    22. XM_047421825.1 → XP_047277781.1  PHD finger protein 20-like protein 1 isoform X15

    23. XM_047421826.1 → XP_047277782.1  PHD finger protein 20-like protein 1 isoform X16

    24. XM_047421827.1 → XP_047277783.1  PHD finger protein 20-like protein 1 isoform X16

    25. XM_017013517.2 → XP_016869006.1  PHD finger protein 20-like protein 1 isoform X17

      UniProtKB/TrEMBL
      A8MUE8
      Related
      ENSP00000378777.1, ENST00000395379.5
      Conserved Domains (2) summary
      cd20454
      Location:86 → 144
      Tudor_PHF20L1; Tudor domain found in PHD finger protein 20-like protein 1 (PHF20L1) and similar proteins
      cl17705
      Location:3 → 68
      MBT; mbt repeat

    26. XM_047421824.1 → XP_047277780.1  PHD finger protein 20-like protein 1 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      133898574..133971990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360553.1 → XP_054216528.1  PHD finger protein 20-like protein 1 isoform X1

    2. XM_054360556.1 → XP_054216531.1  PHD finger protein 20-like protein 1 isoform X3

    3. XM_054360559.1 → XP_054216534.1  PHD finger protein 20-like protein 1 isoform X5

    4. XM_054360561.1 → XP_054216536.1  PHD finger protein 20-like protein 1 isoform X6

    5. XM_054360563.1 → XP_054216538.1  PHD finger protein 20-like protein 1 isoform X7

    6. XM_054360566.1 → XP_054216541.1  PHD finger protein 20-like protein 1 isoform X9

    7. XM_054360569.1 → XP_054216544.1  PHD finger protein 20-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F8W9L8

    8. XM_054360570.1 → XP_054216545.1  PHD finger protein 20-like protein 1 isoform X11

    9. XM_054360554.1 → XP_054216529.1  PHD finger protein 20-like protein 1 isoform X1

    10. XM_054360555.1 → XP_054216530.1  PHD finger protein 20-like protein 1 isoform X2

    11. XM_054360557.1 → XP_054216532.1  PHD finger protein 20-like protein 1 isoform X3

    12. XM_054360558.1 → XP_054216533.1  PHD finger protein 20-like protein 1 isoform X4

    13. XM_054360560.1 → XP_054216535.1  PHD finger protein 20-like protein 1 isoform X5

    14. XM_054360562.1 → XP_054216537.1  PHD finger protein 20-like protein 1 isoform X6

    15. XM_054360564.1 → XP_054216539.1  PHD finger protein 20-like protein 1 isoform X7

    16. XM_054360565.1 → XP_054216540.1  PHD finger protein 20-like protein 1 isoform X8

      UniProtKB/Swiss-Prot
      A8MW92, A8MZC9, Q86U89, Q86W43, Q96BT0, Q9H702, Q9HBK3, Q9NYR3, Q9Y381

    17. XM_054360567.1 → XP_054216542.1  PHD finger protein 20-like protein 1 isoform X9

    18. XM_054360568.1 → XP_054216543.1  PHD finger protein 20-like protein 1 isoform X10

      UniProtKB/TrEMBL
      F8W9L8

    19. XM_054360571.1 → XP_054216546.1  PHD finger protein 20-like protein 1 isoform X11

    20. XM_054360573.1 → XP_054216548.1  PHD finger protein 20-like protein 1 isoform X13

    21. XM_054360574.1 → XP_054216549.1  PHD finger protein 20-like protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A8K9A6

    22. XM_054360575.1 → XP_054216550.1  PHD finger protein 20-like protein 1 isoform X15

    23. XM_054360576.1 → XP_054216551.1  PHD finger protein 20-like protein 1 isoform X16

    24. XM_054360577.1 → XP_054216552.1  PHD finger protein 20-like protein 1 isoform X16

    25. XM_054360578.1 → XP_054216553.1  PHD finger protein 20-like protein 1 isoform X17

    26. XM_054360572.1 → XP_054216547.1  PHD finger protein 20-like protein 1 isoform X12

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024878.1: Suppressed sequence

      Description
      NM_024878.1: This RefSeq was permanently suppressed because it represents actually 5' partial CDS and its 5' sequence was intronic sequence.

    2. NM_032205.3: Suppressed sequence

      Description
      NM_032205.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MW92.2 GenPept UniProtKB/Swiss-Prot:A8MW92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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