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    ZBTB43 zinc finger and BTB domain containing 43 [ Homo sapiens (human) ]

    Gene ID: 23099, updated on 27-Nov-2024

    Summary

    Official Symbol
    ZBTB43provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 43provided by HGNC
    Primary source
    HGNC:HGNC:17908
    See related
    Ensembl:ENSG00000169155 MIM:618676; AllianceGenome:HGNC:17908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF-X; ZBTB22B; ZNF297B
    Summary
    Enables RNA polymerase III general transcription initiation factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bone marrow (RPKM 18.2), testis (RPKM 10.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZBTB43 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (126804072..126838210)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139009454..139043950)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129567319..129600489)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129376359-129376940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129376941-129377520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129378101-129378680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129387803-129388768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129392623-129393190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129393191-129393758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129398978-129399478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129414454-129415333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129416491-129416990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129424890-129425503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129425974-129426490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129426491-129427005 Neighboring gene Sharpr-MPRA regulatory region 8141 Neighboring gene LIM homeobox transcription factor 1 beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129436714-129437369 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:129438749-129439277 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:129439278-129439806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129445577-129446297 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:129450160-129451042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129456574-129457344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129458734-129459234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129464425-129465019 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr9:129467063-129467788 and GRCh37_chr9:129467789-129468514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129468515-129469238 Neighboring gene uncharacterized LOC107987129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129482087-129482586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20291 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129567045-129567546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129594985-129595486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129595487-129595986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29023 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129623061-129623858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129630751-129631332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:129645854-129646429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129648667-129649167 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29025 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29031 Neighboring gene uncharacterized LOC105376279

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 43
    Names
    zinc finger and BTB domain-containing protein 22B
    zinc finger protein 297B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135776.2NP_001129248.1  zinc finger and BTB domain-containing protein 43

      See identical proteins and their annotated locations for NP_001129248.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AL161731, AL354944, DA500531
      Consensus CDS
      CCDS6867.1
      UniProtKB/Swiss-Prot
      O43298, Q5JU96
      Related
      ENSP00000390344.1, ENST00000449886.5
      Conserved Domains (3) summary
      sd00017
      Location:376394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414437
      zf-H2C2_2; Zinc-finger double domain
    2. NM_014007.4NP_054726.1  zinc finger and BTB domain-containing protein 43

      See identical proteins and their annotated locations for NP_054726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AL161731, AL354944, BC008828, DA864775
      Consensus CDS
      CCDS6867.1
      UniProtKB/Swiss-Prot
      O43298, Q5JU96
      Related
      ENSP00000362563.4, ENST00000373464.5
      Conserved Domains (3) summary
      sd00017
      Location:376394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414437
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      126804072..126838210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518409.1XP_011516711.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_011516711.1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
      Conserved Domains (3) summary
      sd00017
      Location:376394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414437
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047423032.1XP_047278988.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    3. XM_005251835.4XP_005251892.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_005251892.1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
      Conserved Domains (3) summary
      sd00017
      Location:376394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414437
      zf-H2C2_2; Zinc-finger double domain
    4. XM_047423031.1XP_047278987.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    5. XM_011518411.3XP_011516713.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_011516713.1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
      Conserved Domains (3) summary
      sd00017
      Location:376394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414437
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      139009454..139043950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362449.1XP_054218424.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    2. XM_054362447.1XP_054218422.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    3. XM_054362448.1XP_054218423.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    4. XM_054362446.1XP_054218421.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96
    5. XM_054362450.1XP_054218425.1  zinc finger and BTB domain-containing protein 43 isoform X1

      UniProtKB/Swiss-Prot
      O43298, Q5JU96