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    MAP7D2 MAP7 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 256714, updated on 10-Dec-2024

    Summary

    Official Symbol
    MAP7D2provided by HGNC
    Official Full Name
    MAP7 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25899
    See related
    Ensembl:ENSG00000184368 MIM:301121; AllianceGenome:HGNC:25899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 8.5), testis (RPKM 4.5) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAP7D2 in Genome Data Viewer
    Location:
    Xp22.12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (20006713..20116907, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19589600..19699784, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20024831..20135025, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905256 Neighboring gene BCLAF1 and THRAP3 family member 3 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:20001035-20001226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20695 Neighboring gene uncharacterized LOC729609 Neighboring gene microRNA 23c Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29477 Neighboring gene EIF1AX antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 1A X-linked Neighboring gene small Cajal body-specific RNA 9 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14503, MGC104944

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    MAP7 domain-containing protein 2
    Names
    MAP7 domain containing 2 brain
    MAP7 domain containing 2 protein varaint 1
    MAP7 domain containing 2 protein varaint 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016371.1 RefSeqGene

      Range
      5090..115284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168465.2NP_001161937.1  MAP7 domain-containing protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AW138738, BC089400, BC136379, R45976
      Consensus CDS
      CCDS55386.1
      UniProtKB/TrEMBL
      A0A0M3R6J9
      Related
      ENSP00000368964.5, ENST00000379643.10
      Conserved Domains (2) summary
      pfam05672
      Location:425603
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_001168466.2NP_001161938.1  MAP7 domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001161938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK296319, AW138738, BC089400, R45976
      Consensus CDS
      CCDS55385.1
      UniProtKB/TrEMBL
      B7ZA02
      Related
      ENSP00000388239.3, ENST00000443379.7
      Conserved Domains (2) summary
      pfam05672
      Location:339510
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. NM_001168467.2NP_001161939.1  MAP7 domain-containing protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (4) maintains the reading frame but is shorter, compared to isoform 1.
      Source sequence(s)
      AK294788, AL732366, AW138738, BC089400, DA409284, R45976
      Consensus CDS
      CCDS55384.1
      UniProtKB/TrEMBL
      A0A0M3R6J9
      Related
      ENSP00000413301.3, ENST00000452324.3
      Conserved Domains (2) summary
      pfam05672
      Location:332510
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:975
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. NM_152780.4NP_689993.2  MAP7 domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_689993.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AW138738, BC037165, BC136379, R45976
      Consensus CDS
      CCDS14195.1
      UniProtKB/Swiss-Prot
      B7Z2J8, B7Z3S7, B9EGC7, C9JMA4, C9JYW0, Q5EBN1, Q5JPS7, Q6PIC7, Q8N792, Q96T17
      UniProtKB/TrEMBL
      A0A0M3R6J9
      Related
      ENSP00000368972.3, ENST00000379651.7
      Conserved Domains (2) summary
      pfam05672
      Location:384562
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      20006713..20116907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274480.4XP_005274537.1  MAP7 domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:376554
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. XM_005274479.3XP_005274536.1  MAP7 domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0K1JS24, A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:398576
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_017029393.2XP_016884882.1  MAP7 domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0M3R6J9, A0A0M4FLI9
      Conserved Domains (2) summary
      pfam05672
      Location:406584
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. XM_011545483.2XP_011543785.1  MAP7 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:447625
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    5. XM_005274478.4XP_005274535.1  MAP7 domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0K1JRJ6, A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:409587
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    6. XM_006724482.3XP_006724545.1  MAP7 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0M3R6J9, A0A0M4F6E1
      Conserved Domains (2) summary
      pfam05672
      Location:417595
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    7. XM_006724481.3XP_006724544.1  MAP7 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:458636
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    8. XM_047441983.1XP_047297939.1  MAP7 domain-containing protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A0M3R6J9
    9. XM_017029397.2XP_016884886.1  MAP7 domain-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      B3KXC0
    10. XM_017029396.2XP_016884885.1  MAP7 domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      B3KXC0
    11. XM_011545485.2XP_011543787.1  MAP7 domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:403581
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:975
      GBP_C; Guanylate-binding protein, C-terminal domain
    12. XM_017029395.3XP_016884884.1  MAP7 domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      B3KXC0
    13. XM_017029394.2XP_016884883.1  MAP7 domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A0M3R6J9
    14. XM_011545484.2XP_011543786.1  MAP7 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0M3R6J9
      Conserved Domains (2) summary
      pfam05672
      Location:414592
      MAP7; MAP7 (E-MAP-115) family
      cl20817
      Location:975
      GBP_C; Guanylate-binding protein, C-terminal domain
    15. XM_017029398.3XP_016884887.1  MAP7 domain-containing protein 2 isoform X19

    16. XM_047441985.1XP_047297941.1  MAP7 domain-containing protein 2 isoform X18

    17. XM_024452362.2XP_024308130.1  MAP7 domain-containing protein 2 isoform X16

      Conserved Domains (2) summary
      pfam05914
      Location:40119
      RIB43A
      cl25742
      Location:425452
      ERM; Ezrin/radixin/moesin family
    18. XM_011545486.4XP_011543788.1  MAP7 domain-containing protein 2 isoform X15

      Conserved Domains (1) summary
      cl20817
      Location:53119
      GBP_C; Guanylate-binding protein, C-terminal domain
    19. XM_047441984.1XP_047297940.1  MAP7 domain-containing protein 2 isoform X17

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      19589600..19699784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326806.1XP_054182781.1  MAP7 domain-containing protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A0M3R6J9
    2. XM_054326805.1XP_054182780.1  MAP7 domain-containing protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A0K1JS24, A0A0M3R6J9
    3. XM_054326803.1XP_054182778.1  MAP7 domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A0M3R6J9, A0A0M4FLI9
    4. XM_054326799.1XP_054182774.1  MAP7 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0M3R6J9
    5. XM_054326802.1XP_054182777.1  MAP7 domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A0K1JRJ6, A0A0M3R6J9
    6. XM_054326800.1XP_054182775.1  MAP7 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0M3R6J9, A0A0M4F6E1
    7. XM_054326798.1XP_054182773.1  MAP7 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0M3R6J9
    8. XM_054326811.1XP_054182786.1  MAP7 domain-containing protein 2 isoform X14

      UniProtKB/TrEMBL
      A0A0M3R6J9
    9. XM_054326810.1XP_054182785.1  MAP7 domain-containing protein 2 isoform X13

      UniProtKB/TrEMBL
      B3KXC0
    10. XM_054326809.1XP_054182784.1  MAP7 domain-containing protein 2 isoform X12

      UniProtKB/TrEMBL
      B3KXC0
    11. XM_054326804.1XP_054182779.1  MAP7 domain-containing protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0M3R6J9
    12. XM_054326808.1XP_054182783.1  MAP7 domain-containing protein 2 isoform X11

      UniProtKB/TrEMBL
      B3KXC0
    13. XM_054326807.1XP_054182782.1  MAP7 domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A0M3R6J9
    14. XM_054326801.1XP_054182776.1  MAP7 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0M3R6J9
    15. XM_054326816.1XP_054182791.1  MAP7 domain-containing protein 2 isoform X19

    16. XM_054326815.1XP_054182790.1  MAP7 domain-containing protein 2 isoform X18

    17. XM_054326812.1XP_054182787.1  MAP7 domain-containing protein 2 isoform X15

    18. XM_054326814.1XP_054182789.1  MAP7 domain-containing protein 2 isoform X17

    19. XM_054326813.1XP_054182788.1  MAP7 domain-containing protein 2 isoform X16