Atg8a Autophagy-related 8a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg8aprovided by FlyBase
Official Full Name: Autophagy-related 8aprovided by FlyBase
Primary source: FLYBASE:FBgn0052672
Locus tag: Dmel_CG32672
See related: AllianceGenome:FB:FBgn0052672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: agt8a; Atg-8a; atg8; Atg8; ATG8; Atg8/LC3; ATG8/LC3; atg8a; atg8A; Atg8A; ATG8a; ATG8A; Atg8alpha; BcDNA:LD05816; CG1534; CG32672; dAtg8; dAtg8a; DmAtg8a; Dmel\CG32672; DrAtg8a; LC3; LC3/Atg8
Summary: Enables protein kinase binding activity. Involved in several processes, including determination of adult lifespan; larval midgut cell programmed cell death; and reticulophagy. Located in amphisome; autolysosome; and type I terminal bouton. Is expressed in adult head and ovary. Orthologous to several human genes including GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10764878..10768338, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10658911..10662371, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
Title: The two autophagy-related proteins 8a and 8b play distinct physiological roles in Drosophila.
Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
Title: Analysis of Drosophila Atg8 proteins reveals multiple lipidation-independent roles.
DmAtg8a interacts directly with DmKeap1, and DmKeap1 is removed upon programmed autophagy in Drosophila gut cells
Title: p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB.
The transmembrane protein Atg9 accumulates on refractory to Sigma P (Ref(2)P) aggregates in Atg7, Atg8a and Atg2 mutants
Title: Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.
Enhanced Atg8a expression in older fly brains extends the average adult lifespan by 56% and promotes resistance to oxidative stress and the accumulation of ubiquitinated and oxidized proteins.
Title: Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IEP Inferred from Expression Pattern more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in amphisome	IDA Inferred from Direct Assay more info	PubMed
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed

Names: Atg8a-PA; Atg8a-PB; Atg8a-PC; Autophagy-specific gene 8a; CG32672-PA; CG32672-PB; CG32672-PC; autophagy-related 8 protein; autophagy-related 8a

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The following sections contain reference sequences that belong to a specific genome build. Explain