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    RPA3 Replication protein A3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32113, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RPA3provided by FlyBase
    Official Full Name
    Replication protein A3provided by FlyBase
    Primary source
    FLYBASE:FBgn0288833
    Locus tag
    Dmel_CG15220
    See related
    AllianceGenome:FB:FBgn0288833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH55360; CG15220; D-SSB; Dmel\CG15220; DmRPA; dRP-A; DRP-A; l(1)G0241; RP-A; RPA; RpA-8; Ssb-8
    Summary
    Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Involved in neuronal stem cell population maintenance. Located in nucleus. Is expressed in larval brain; larval outer optic anlage; larval ventral nerve cord; medulla forming neuroblast; and optic lobe neuroepithelial cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RPA3 in Genome Data Viewer
    Location:
    10D1-10D1; 1-35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11615097..11615840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11509130..11509873, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene rhomboid-4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Methoprene-tolerant Neighboring gene Protein tyrosine phosphatase 10D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos. Thömmes P, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501468, Free PMC Article
    2. Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster. Mitsis PG. Dev Biol, 1995 Aug. PMID 7649375
    3. A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product. Oshige M, et al. Mutat Res, 1999 Apr 9. PMID 10343651
    4. Simian virus 40 origin- and T-antigen-dependent DNA replication with Drosophila factors in vitro. Kamakaka RT, et al. Mol Cell Biol, 1994 Aug. PMID 8035793, Free PMC Article
    5. Purification and characterisation of dRP-A: a single-stranded DNA binding protein from Drosophila melanogaster. Marton RF, et al. FEBS Lett, 1994 Apr 4. PMID 8143866

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A3
    Names
    CG15220-PA
    CG15220-PB
    RPA3-PA
    RPA3-PB
    drosophila replication protein A
    lethal (1) G0241
    replication protein A
    replication protein A 8
    single stranded-binding protein 8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11615097..11615840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298202.1 → NP_001285131.1  replication protein A3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285131.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYW3
      Conserved Domains (1) summary
      pfam08661
      Location:1 → 109
      Rep_fac-A_3; Replication factor A protein 3

    2. NM_132509.2 → NP_572737.1  replication protein A3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYW3
      Related
      FBpp0073380
      Conserved Domains (1) summary
      pfam08661
      Location:1 → 109
      Rep_fac-A_3; Replication factor A protein 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYW3 Q9VYW3

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