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    CG2577 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32188, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2577provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030384
    Locus tag
    Dmel_CG2577
    See related
    AllianceGenome:FB:FBgn0030384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2577
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endocytosis; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Orthologous to human CSNK1A1 (casein kinase 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2577 in Genome Data Viewer
    Location:
    11A9-11A9; 1-38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12373118..12374448)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12267151..12268481)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Tenascin accessory Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 11a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of casein kinase 1 and functional analysis of new doubletime mutants in Drosophila. Thakkar N, et al. Front Physiol, 2022. PMID 36589447, Free PMC Article
    2. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Meng Z, et al. Mol Biol Cell, 2011 Aug 15. PMID 21680713, Free PMC Article
    3. Regulation of wingless signaling by the CKI family in Drosophila limb development. Zhang L, et al. Dev Biol, 2006 Nov 1. PMID 16987508, Free PMC Article
    4. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Housden BE, et al. Sci Signal, 2015 Sep 8. PMID 26350902, Free PMC Article
    5. Integrated omics in Drosophila uncover a circadian kinome. Wang C, et al. Nat Commun, 2020 Jun 1. PMID 32483184, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2577-PA
    CKIa-like
    NP_572794.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12373118..12374448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132566.2 → NP_572794.1  uncharacterized protein Dmel_CG2577 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYN5
      Related
      FBpp0073476
      Conserved Domains (2) summary
      COG0515
      Location:16 → 242
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14016
      Location:16 → 281
      STKc_CK1; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYN5 Q9VYN5

    Gene LinkOut

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