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    MFS10 Major Facilitator Superfamily Transporter 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFS10provided by FlyBase
    Official Full Name
    Major Facilitator Superfamily Transporter 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0030452
    Locus tag
    Dmel_CG4330
    See related
    AllianceGenome:FB:FBgn0030452
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AA202479; CG4330; Dmel\CG4330
    Summary
    Predicted to enable transmembrane transporter activity. Involved in negative regulation of cell population proliferation and phosphate ion transport. Predicted to be active in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MFS10 in Genome Data Viewer
    Location:
    11E1-11E1; 1-42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13129018..13134839)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13023051..13028872)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 204 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster. Rollmann SM, et al. Nat Genet, 2006 Jul. PMID 16783380
    2. A phosphate-sensing organelle regulates phosphate and tissue homeostasis. Xu C, et al. Nature, 2023 May. PMID 37138087, Free PMC Article
    3. Roles of major facilitator superfamily transporters in phosphate response in Drosophila. Bergwitz C, et al. PLoS One, 2012. PMID 22359624, Free PMC Article
    4. Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. Gonsalves SE, et al. BMC Genomics, 2011 Sep 29. PMID 21958154, Free PMC Article
    5. Discriminant analysis to evaluate clustering of gene expression data. Méndez MA, et al. FEBS Lett, 2002 Jul 3. PMID 12095613

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily transporter 10
    Names
    CG4330-PA
    CG4330-PB
    CG4330-PC
    MFS10-PA
    MFS10-PB
    MFS10-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13129018..13134839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298259.1 → NP_001285188.1  major facilitator superfamily transporter 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTZ7, Q9VYG7
      Conserved Domains (2) summary
      cd06174
      Location:134 → 538
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:63 → 547
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_001298260.1 → NP_001285189.1  major facilitator superfamily transporter 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTZ7, Q9VYG7
      Conserved Domains (2) summary
      cd06174
      Location:134 → 538
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:63 → 547
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    3. NM_132629.2 → NP_572857.1  major facilitator superfamily transporter 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTZ7, Q9VYG7
      Related
      FBpp0073555
      Conserved Domains (2) summary
      cd06174
      Location:134 → 538
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:63 → 547
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YTZ7 Q7YTZ7
    Q9VYG7 Q9VYG7

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