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    CG11164 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11164provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030507
    Locus tag
    Dmel_CG11164
    See related
    AllianceGenome:FB:FBgn0030507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11164
    Summary
    Predicted to be involved in RNA catabolic process. Predicted to be part of ribonuclease H2 complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including antennal anlage; ganglia; head epidermis primordium; mesoderm; and somatic precursor cell. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11164 in Genome Data Viewer
    Location:
    12B2-12B2; 1-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13668014..13669573)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13562047..13563606)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NFAT nuclear factor Neighboring gene DNA ligase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent. McVey M, et al. Genetics, 2004 Dec. PMID 15611176, Free PMC Article
    2. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
    3. Promoter-Proximal Chromatin Domain Insulator Protein BEAF Mediates Local and Long-Range Communication with a Transcription Factor and Directly Activates a Housekeeping Promoter in Drosophila. Dong Y, et al. Genetics, 2020 May. PMID 32179582, Free PMC Article
    4. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Jiang N, et al. Mol Cell Biol, 2009 Jul. PMID 19380483, Free PMC Article
    5. Expression profiling of glial genes during Drosophila embryogenesis. Altenhein B, et al. Dev Biol, 2006 Aug 15. PMID 16762338

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease H2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease H2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11164-PA
    CG11164-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13668014..13669573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298291.1 → NP_001285220.1  uncharacterized protein Dmel_CG11164, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU33, Q9VYA4
      Conserved Domains (1) summary
      cd09270
      Location:39 → 338
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids

    2. NM_132680.3 → NP_572908.2  uncharacterized protein Dmel_CG11164, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572908.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU33, Q9VYA4
      Related
      FBpp0073640
      Conserved Domains (1) summary
      cd09270
      Location:39 → 338
      RNase_H2-B; Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYN7 Q8SYN7
    Q9VYA4 Q9VYA4

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