if inflated [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ifprovided by FlyBase
Official Full Name: inflatedprovided by FlyBase
Primary source: FLYBASE:FBgn0001250
Locus tag: Dmel_CG9623
See related: AllianceGenome:FB:FBgn0001250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha-PS2; alpha2Int; alphaPS2; alphaPS2 integrin; alphaPS2C; alphaPS2m8; alpha[[PS2(ms8)]]; alpha[[PS2]]; aPS2; CG9623; CT27194; Dmel\CG9623; If; IF; in; inf; Integrin alpha PS2; ItgaPS2; PS 2; PS2; PS2(c); PS2(m8); PS2(m8)alpha; PS2alpha; PSalpha2
Summary: Enables extracellular matrix binding activity and protein heterodimerization activity. Contributes to extracellular matrix protein binding activity. Involved in several processes, including border follicle cell migration; hemocyte migration; and nervous system development. Located in basal plasma membrane; focal adhesion; and sarcolemma. Part of integrin complex. Is expressed in several structures, including adult brain; adult head; adult heart; epithelium; and muscle cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; blood platelet disease (multiple); end stage renal disease; renal agenesis; and von Willebrand's disease 1. Orthologous to several human genes including ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 15A5-15A7; 1-55 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16752189..16783434, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16646222..16677467, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tenectin (Tnc) selectively recruits alphaPS2 integrin (alphaPS2/betaPS) integrin at synaptic terminals, but only the cis Tnc/integrin complexes appear to be biologically active
Title: Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction.
the conserved transmembrane Drosophila proteoglycan Kon-tiki (Kon, also known as Perdido) interacts with the alphaPS2betaPS integrin (alphaPS2 is encoded by inflated and betaPS by myospheroid) to mediate muscle-tendon adhesion.
Title: Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
the integrin heterodimer alphaPS3/betaPS becomes apically enriched and is required for engulfment by the epithelial follicle cells of the Drosophila ovary.
Title: Polarization of the epithelial layer and apical localization of integrins are required for engulfment of apoptotic cells in the Drosophila ovary.
Study presents evidence that alphaPS2 and alphaPS3 integrin have different and specific functions in the development of retinal glia
Title: Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions.
Data indicate that Tsp66E and Tsp74F mutant ovaries had elevated inflated gene product alphaPS2 integrin levels and reduced endocytic trafficking.
Title: Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization.
These data suggest a model in which ERK phosphorylation must be spatially coupled to integrin-mediated DIM-7 activation to make a complex that can be imported efficiently.
Title: Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.
Alternative splicing in integrin alpha subunit extracellular domains may affect ligand affinity via relatively subtle alterations in integrin conformation.
Title: Modulation of ligand binding by alternative splicing of the alphaPS2 integrin subunit.
Three mutations that alter different parts of the alphaPS2 beta-propeller, plus a fourth that eliminated a late phase of alphaPS2 expression, all led to a strong decrease in alphaPS2betaPS at muscle ends, but normal levels of talin were recruited.
Title: Mutations in the Drosophila alphaPS2 integrin subunit uncover new features of adhesion site assembly.
analysis of binding by Drosophila alphaPS2betaPS integrin to ligands
Title: Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.
interaction with gene encoding moleskin
Title: Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to extracellular matrix protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	NAS Non-traceable Author Statement more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal defasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in central nervous system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of epithelial integrity, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in salivary gland morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of integrin complex	NAS Non-traceable Author Statement more info	PubMed
part_of integrin complex	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inflated

Names: CG9623-PB; CG9623-PC; CG9623-PD; CG9623-PF; PS II alpha; alpha integrin; alpha-PS2-integrin; alpha-integrin; alpha2 integrin; alphaPS2; alphaPS2 integrin; alphaPS2-integrin; alpha[[PS2]] integrin; if-PB; if-PC; if-PD; if-PF; integrin; integrin PSI alpha subunit; integrin alpha PS2; integrin alphaPS2 subunit; position-specific antigen 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

16752189..16783434 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167544.2 → NP_728021.2 inflated, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728021.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P12080

Conserved Domains (3) summary

smart00191
Location:373 → 426

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:474 → 868

Integrin_alpha2; Integrin alpha

cl08110
Location:1095 → 1153

DUF2756; Protein of unknown function (DUF2756)
NM_078654.2 → NP_523378.2 inflated, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523378.2

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JJN2, P12080, Q8IR07, Q8MSG3, Q9VXB6

Related

FBpp0074131, FBtr0074357

Conserved Domains (3) summary

smart00191
Location:398 → 451

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:499 → 893

Integrin_alpha2; Integrin alpha

cl08110
Location:1120 → 1178

DUF2756; Protein of unknown function (DUF2756)
NM_001169306.2 → NP_001162777.1 inflated, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162777.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JJN2, P12080, Q8IR07, Q8MSG3, Q9VXB6

Conserved Domains (3) summary

smart00191
Location:398 → 451

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:499 → 893

Integrin_alpha2; Integrin alpha

cl08110
Location:1120 → 1178

DUF2756; Protein of unknown function (DUF2756)
NM_001169307.1 → NP_001162778.1 inflated, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162778.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JJN2, P12080, Q8IR07, Q8MSG3, Q9VXB6

Conserved Domains (3) summary

smart00191
Location:398 → 451

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:499 → 893

Integrin_alpha2; Integrin alpha

cl08110
Location:1120 → 1178

DUF2756; Protein of unknown function (DUF2756)