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    CG46280 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067077, updated on 4-Jan-2025

    Summary

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    Official Symbol
    CG46280provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283438
    Locus tag
    Dmel_CG46280
    See related
    AllianceGenome:FB:FBgn0283438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12360; Dmel\CG46280
    Summary
    Predicted to enable mitochondrion-mitochondrion outer membrane tether activity. Involved in mitochondrial fusion. Is active in mitochondrial outer membrane. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and gut section. Used to study neurodegenerative disease. Orthologous to human TRABD (TraB domain containing). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See CG46280 in Genome Data Viewer
    Location:
    87D9-87D9; 3-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13026283..13030659, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene C-terminal Binding Protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) 87Df Neighboring gene rosy

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_033777.3 Chromosome 3R Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRABD modulates mitochondrial homeostasis and tissue integrity. Zhou C, et al. Cell Rep, 2024 Jun 25. PMID 38843396
    2. Regulators of autophagosome formation in Drosophila muscles. Zirin J, et al. PLoS Genet, 2015 Feb. PMID 25692684, Free PMC Article
    3. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mitochondrion-mitochondrion outer membrane tether activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG46280-PA
    CG46280-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13026283..13030659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169493.3 → NP_731765.1  uncharacterized protein Dmel_CG46280, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG01
      Conserved Domains (1) summary
      cl12050
      Location:251 → 444
      TraB; TraB family

    2. NM_141996.3 → NP_650253.1  uncharacterized protein Dmel_CG46280, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG01
      Conserved Domains (1) summary
      cl12050
      Location:251 → 444
      TraB; TraB family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG01 Q9VG01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases