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    Droj2 DnaJ-like-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41646, updated on 9-Dec-2024

    Summary

    Official Symbol
    Droj2provided by FlyBase
    Official Full Name
    DnaJ-like-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038145
    Locus tag
    Dmel_CG8863
    See related
    AllianceGenome:FB:FBgn0038145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.404; CG8863; Dmel\CG8863; DnaJL2A; DROJ2; Hsp40
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Droj2 in Genome Data Viewer
    Location:
    87E8-87E8; 3-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13382106..13385283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9207828..9211005)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44138 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene uncharacterized protein Neighboring gene CCHamide-2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DnaJ-like-2
    Names
    CG8863-PA
    CG8863-PB
    CG8863-PC
    CG8863-PD
    CG8863-PE
    DnaJ-like-2 chaperone
    Droj2-PA
    Droj2-PB
    Droj2-PC
    Droj2-PD
    Droj2-PE

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13382106..13385283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142026.3NP_650283.1  DnaJ-like-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082219
      Conserved Domains (4) summary
      cd10719
      Location:140206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain
    2. NM_169522.2NP_731807.1  DnaJ-like-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082223
      Conserved Domains (4) summary
      cd10719
      Location:140206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain
    3. NM_169519.2NP_731804.1  DnaJ-like-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082220
      Conserved Domains (4) summary
      cd10719
      Location:140206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain
    4. NM_169520.2NP_731805.1  DnaJ-like-2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082221
      Conserved Domains (4) summary
      cd10719
      Location:140206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain
    5. NM_169521.2NP_731806.1  DnaJ-like-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082222
      Conserved Domains (4) summary
      cd10719
      Location:140206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:765
      DnaJ; DnaJ domain