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    Non3 Novel nucleolar protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Non3provided by FlyBase
    Official Full Name
    Novel nucleolar protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038585
    Locus tag
    Dmel_CG7993
    See related
    AllianceGenome:FB:FBgn0038585
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7993; Dmel\CG7993
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in several structures, including anal pad primordium; embryonic/larval midgut primordium; mesoderm; muscle cell; and visceral muscle primordium. Orthologous to human RPF2 (ribosome production factor 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Non3 in Genome Data Viewer
    Location:
    90F8-90F8; 3-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18223722..18224942)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14049444..14050664)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription termination factor 5 Neighboring gene uncharacterized protein Neighboring gene Malate dehydrogenase 2 Neighboring gene reversed polarity Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The archaeal homolog of the Imp4 protein, a eukaryotic U3 snoRNP component. Mayer C, et al. Trends Biochem Sci, 2001 Mar. PMID 11246005
    2. New Functional Motifs for the Targeted Localization of Proteins to the Nucleolus in Drosophila and Human Cells. Ogienko AA, et al. Int J Mol Sci, 2024 Jan 19. PMID 38279227, Free PMC Article
    3. Genes involved in centrosome-independent mitotic spindle assembly in Drosophila S2 cells. Moutinho-Pereira S, et al. Proc Natl Acad Sci U S A, 2013 Dec 3. PMID 24255106, Free PMC Article
    4. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, et al. iScience, 2022 Sep 16. PMID 36060064, Free PMC Article
    5. Functional genomics identifies TOR-regulated genes that control growth and division. Guertin DA, et al. Curr Biol, 2006 May 23. PMID 16713952

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative nucleolar protein 3
    Names
    CG7993-PA
    Non3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18223722..18224942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142437.3 → NP_650694.2  putative nucleolar protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650694.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95U84, Q9VEB3
      UniProtKB/TrEMBL
      B5RJN7
      Related
      FBpp0082984
      Conserved Domains (1) summary
      cl00935
      Location:3 → 290
      Brix; Brix domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEB3.3 Q9VEB3

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