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    Mtl Mig-2-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtlprovided by FlyBase
    Official Full Name
    Mig-2-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039532
    Locus tag
    Dmel_CG5588
    See related
    AllianceGenome:FB:FBgn0039532
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5588; CG5588; Dmel\CG5588; dMig-2; Mt1/Mig2-like; mtl; MTL; Rac; Rac GTPase; Rac-like; Rac3
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; establishment of planar polarity; and hemocyte migration. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mtl in Genome Data Viewer
    Location:
    98A13-98A13; 3-94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27636412..27639871)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23462134..23465593)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tusp Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-1001 stem loop Neighboring gene tau Neighboring gene Ribosomal protein S10a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mtl interacts with members of Egfr signaling and cell adhesion genes in the Drosophila eye. Muñoz-Soriano V, et al. Fly (Austin), 2011 Apr-Jun. PMID 21441778
    2. Drosophila adhesion GPCR Remoulade regulates axon growth, branching, and guidance by modulating Rac1 GTPase. Yang X, et al. J Genet Genomics, 2024 Apr. PMID 38049063
    3. Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis. Bosch DE, et al. Structure, 2013 Jan 8. PMID 23260656, Free PMC Article
    4. Drosophila RhoGAP18B regulates actin cytoskeleton during border cell migration. Lei F, et al. PLoS One, 2023. PMID 36662713, Free PMC Article
    5. Rac function and regulation during Drosophila development. Hakeda-Suzuki S, et al. Nature, 2002 Mar 28. PMID 11919634

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, elongation of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in head involution IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesodermal cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of wound healing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mig-2-like
    Names
    CG5588-PA
    CG5588-PB
    CG5588-PC
    Mtl(Rac-like)
    Mtl-PA
    Mtl-PB
    Mtl-PC
    Rac
    Rac GTPase
    mig-2-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27636412..27639871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170344.2 → NP_733223.1  Mig-2-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWS8
      Related
      FBpp0084561
      Conserved Domains (1) summary
      smart00174
      Location:9 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

    2. NM_079809.3 → NP_524533.1  Mig-2-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWS8
      Related
      FBpp0084562
      Conserved Domains (1) summary
      smart00174
      Location:9 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

    3. NM_170343.2 → NP_733222.1  Mig-2-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWS8
      Related
      FBpp0084563
      Conserved Domains (1) summary
      smart00174
      Location:9 → 182
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWS8 Q7JWS8

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