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    Sin3A Sin3A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36382, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sin3Aprovided by FlyBase
    Official Full Name
    Sin3Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0022764
    Locus tag
    Dmel_CG8815
    See related
    AllianceGenome:FB:FBgn0022764
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    159A11T; 27/3; 97/15; CG8815; Dmel\CG8815; dSin3; dSin3A; ES2-3; ESTS:159A11T; EY2-9; l(2)08269; l(2)k02703; l(2)k05415; l(2)k09715; ld; Sin 3A; sin3; Sin3; SIN3; sin3a; sin3A; Sin3a; SIN3A; sni3
    Summary
    Enables chromatin binding activity and protein heterodimerization activity. Involved in several processes, including determination of adult lifespan; larval somatic muscle development; and regulation of DNA-templated transcription. Located in chromatin; nucleus; and polytene chromosome. Part of Sin3-type complex and transcription repressor complex. Is expressed in organism. Used to study cancer and developmental disorder of mental health. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sin3A in Genome Data Viewer
    Location:
    49B5-49B7; 2-67 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12575240..12592917, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8462745..8480422, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 301a1 Neighboring gene Adenylate kinase 6 Neighboring gene stand still Neighboring gene Chloride channel-b Neighboring gene long non-coding RNA:CR30055 Neighboring gene long non-coding RNA:CR45279 Neighboring gene long non-coding RNA:CR43909 Neighboring gene Amphiphysin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sin3: insight into its transcription regulatory functions. Kadamb R, et al. Eur J Cell Biol, 2013 Aug-Sep. PMID 24189169
    2. Chromatin: the old and young of it. Emerson FJ, et al. Front Mol Biosci, 2023. PMID 37877123, Free PMC Article
    3. Drosophila SIN3 is required at multiple stages of development. Sharma V, et al. Dev Dyn, 2008 Oct. PMID 18816856
    4. Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3. Chaubal A, et al. J Biol Chem, 2016 May 27. PMID 27129248, Free PMC Article
    5. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription. Liu M, et al. J Biol Chem, 2020 Jan 10. PMID 31776190, Free PMC Article

    See all (187) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
      Title: A complex interplay between SAM synthetase and the epigenetic regulator SIN3 controls metabolism and transcription.
    2. Sin3A promotes Notch transcription. Notch autoregulates its own transcription and this is mediated by Sin3A.
      Title: A positive role of Sin3A in regulating Notch signaling during Drosophila wing development.
    3. findings suggest that while individual SIN3 complex components work through distinct molecular mechanisms, they each make a substantial contribution to the overall function of this highly conserved histone deacetylase complex
      Title: Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.
    4. Ttk69 causes the histone deacetylation-mediated repression of tll via the interaction of Pits and Sin3A
      Title: Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation.
    5. study reveals that SIN3 is an important epigenetic regulator directly connecting methionine metabolism and histone modification.
      Title: The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism.
    6. Sin3A as a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity.
      Title: Whole-genome analysis of muscle founder cells implicates the chromatin regulator Sin3A in muscle identity.
    7. Adult flies with knockdown Sin3A had reduced climbing ability and were more sensitive to oxidative stress. Sin3A knockdown flies had decreased longevity compared to wild type, but no changes in expression of many well-categorized aging genes were observed
      Title: SIN3 is critical for stress resistance and modulates adult lifespan.
    8. data suggest that Sin3A influences a specific step of tumorigenesis by regulating a module of genes involved in cell invasion
      Title: Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors.
    9. Sin3A plays a wide variety of roles in a developing tissue such as the wing disc and that its function is not limited to regulating the cell cycle.
      Title: Identification of genetic suppressors of the Sin3A knockdown wing phenotype.
    10. SIN3 isoforms serve distinct roles in transcriptional regulation by partnering with different histone-modifying enzymes
      Title: Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epithelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sin3A
    Names
    CG8815-PA
    CG8815-PB
    CG8815-PC
    CG8815-PD
    CG8815-PE
    CG8815-PF
    CG8815-PG
    CG8815-PH
    CG8815-PI
    CG8815-PJ
    Sin3A-PA
    Sin3A-PB
    Sin3A-PC
    Sin3A-PD
    Sin3A-PE
    Sin3A-PF
    Sin3A-PG
    Sin3A-PH
    Sin3A-PI
    Sin3A-PJ
    enhancer of GMR-sina 2-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12575240..12592917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165916.3 → NP_725188.1  Sin3A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725188.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77025, Q5U0Y0
      Related
      FBpp0087000
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    2. NM_001201984.2 → NP_001188913.1  Sin3A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z927, O17142
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    3. NM_165915.3 → NP_725187.1  Sin3A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77025, Q5U0Y0
      Related
      FBpp0087003
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    4. NM_136955.4 → NP_610799.2  Sin3A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610799.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z927, O17142
      Related
      FBpp0087001
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    5. NM_001299426.1 → NP_001286355.1  Sin3A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF93, O17143
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    6. NM_001316418.1 → NP_001303347.1  Sin3A, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUN9, O17143
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    7. NM_165917.4 → NP_725189.1  Sin3A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725189.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z928, O17143
      Related
      FBpp0087002
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    8. NM_001299425.1 → NP_001286354.1  Sin3A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF82, O77025
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1713
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1133
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1496 → 1704
      Sin3a_C; C-terminal domain of Sin3a protein

    9. NM_001201983.2 → NP_001188912.1  Sin3A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77025, Q5U0Y0
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1715
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1129
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1498 → 1706
      Sin3a_C; C-terminal domain of Sin3a protein

    10. NM_001259353.2 → NP_001246282.1  Sin3A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K765, O77025
      Conserved Domains (4) summary
      COG5602
      Location:238 → 1719
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:291 → 335
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:1034 → 1133
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1502 → 1710
      Sin3a_C; C-terminal domain of Sin3a protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K765 A0A0B4K765
    A0A0B4LF82 A0A0B4LF82
    A0A0B4LF93 A0A0B4LF93
    A0A126GUN9 A0A126GUN9
    A1Z927 A1Z927
    A1Z928 A1Z928
    O17142 O17142
    O17143 O17143
    O77025 O77025
    Q5U0Y0 Q5U0Y0
    Q960C3 Q960C3

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