ACOX1 acyl-CoA oxidase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ACOX1provided by FlyBase
Official Full Name: acyl-CoA oxidase 1provided by FlyBase
Primary source: FLYBASE:FBgn0027572
Locus tag: Dmel_CG5009
See related: AllianceGenome:FB:FBgn0027572
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH07485; CG5009; dACOX1; Dmel\CG5009; GH07485
Summary: Enables protein homodimerization activity. Involved in hydrogen peroxide biosynthetic process and very long-chain fatty acid beta-oxidation. Predicted to be active in peroxisome. Is expressed in adult heart; anlage in statu nascendi; glial cell; trunk mesoderm; and trunk mesoderm anlage. Used to study Mitchell syndrome. Human ortholog(s) of this gene implicated in Mitchell syndrome and peroxisomal acyl-CoA oxidase deficiency. Orthologous to human ACOX1 (acyl-CoA oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 54E8-54E8; 2-84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17760940..17764541)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13648445..13652046)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.
Title: Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0924 (e-PCR)
- UniSTS:29771

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA oxidase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in generation of precursor metabolites and energy	ISS Inferred from Sequence or Structural Similarity more info
involved_in hydrogen peroxide biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in very long-chain fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: acyl-CoA oxidase 1

Names: ACOX1-PA; CG5009-PA

NP_611264.2

EC 1.3.-.-

EC 1.3.3.6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

17760940..17764541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137420.3 → NP_611264.2 acyl-CoA oxidase 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611264.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KML2, Q95ST5

UniProtKB/TrEMBL

B5RIN5

Related

FBpp0088517

Conserved Domains (2) summary

cd01150
Location:8 → 645

AXO; Peroxisomal acyl-CoA oxidase

PLN02443
Location:10 → 669

PLN02443; acyl-coenzyme A oxidase