EMRE Essential MCU regulator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: EMREprovided by FlyBase
Official Full Name: Essential MCU regulatorprovided by FlyBase
Primary source: FLYBASE:FBgn0062440
Locus tag: Dmel_CG17680
See related: AllianceGenome:FB:FBgn0062440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE55001; CG17680; Dmel\CG17680
Summary: Enables calcium channel activity. Involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be part of uniplex complex. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18147297..18147997, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14034802..14035502, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

EMRE loss blocks fast mitochondrial calcium uptake but is relatively benign.
Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info
part_of uniplex complex	TAS Traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain