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    axed axundead [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    axedprovided by FlyBase
    Official Full Name
    axundeadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035708
    Locus tag
    Dmel_CG8398
    See related
    AllianceGenome:FB:FBgn0035708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey31; Axed; CG8398; Dmel\CG8398
    Summary
    Predicted to be involved in neurogenesis. Predicted to be active in cytosol. Is expressed in adult brain; adult head; larval ventral nerve cord; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See axed in Genome Data Viewer
    Location:
    65C1-65C1; 3-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6609325..6619113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6602425..6612213)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 5 Neighboring gene long non-coding RNA:CR45418 Neighboring gene zero population growth Neighboring gene Glutamate receptor IA Neighboring gene long non-coding RNA:CR45238

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Programmed axon degeneration: from mouse to mechanism to medicine. Coleman MP, et al. Nat Rev Neurosci, 2020 Apr. PMID 32152523, Free PMC Article
    2. Axon death signalling in Wallerian degeneration among species and in disease. Llobet Rosell A, et al. Open Biol, 2019 Aug 30. PMID 31455157, Free PMC Article
    3. Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration. Farley JE, et al. Proc Natl Acad Sci U S A, 2018 Feb 6. PMID 29295933, Free PMC Article
    4. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
    5. The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle. Shapira S, et al. Mol Cell Biol, 2011 Nov. PMID 21930794, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    axundead
    Names
    CG8398-PA
    CG8398-PC
    CG8398-PD
    CG8398-PE
    CG8398-PF
    axed-PA
    axed-PC
    axed-PD
    axed-PE
    axed-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6609325..6619113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370050.1 → NP_001356975.1  axundead, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K4X9, C9QPJ5
      Conserved Domains (2) summary
      smart00225
      Location:192 → 258
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl28903
      Location:354 → 423
      BACK; BACK (BTB and C-terminal Kelch) domain

    2. NM_139794.3 → NP_648051.1  axundead, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ5, Q9VRX8
      Related
      FBpp0076687
      Conserved Domains (2) summary
      smart00225
      Location:192 → 258
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:348 → 442
      BACK; BTB And C-terminal Kelch

    3. NM_206283.2 → NP_996005.1  axundead, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1K1, Q6AWD2, Q8T8V7
      Conserved Domains (2) summary
      smart00225
      Location:90 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:246 → 340
      BACK; BTB And C-terminal Kelch

    4. NM_168174.3 → NP_729180.1  axundead, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1K1, Q6AWD2, Q8T8V7
      Related
      FBpp0076689
      Conserved Domains (2) summary
      smart00225
      Location:90 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:246 → 340
      BACK; BTB And C-terminal Kelch

    5. NM_168173.2 → NP_729179.1  axundead, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1K1, Q6AWD2, Q8T8V7
      Related
      FBpp0303217
      Conserved Domains (2) summary
      smart00225
      Location:90 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:246 → 340
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K4X9 A0A4D6K4X9
    A4V1K1 A4V1K1
    Q9VRX8 Q9VRX8

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