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    DCX-EMAP Doublecortin-domain-containing echinoderm-microtubule-associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39617, updated on 17-Dec-2024

    Summary

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    Official Symbol
    DCX-EMAPprovided by FlyBase
    Official Full Name
    Doublecortin-domain-containing echinoderm-microtubule-associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259099
    Locus tag
    Dmel_CG42247
    See related
    AllianceGenome:FB:FBgn0259099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-71Aa; CG13466; CG13467; CG42247; Dmel\CG42247; dmEMAP
    Old locus tag
    Dmel_CG13466; Dmel_CG13467
    Summary
    Enables microtubule binding activity and microtubule stabilizing activity. Involved in several processes, including cellular response to mechanical stimulus; melanotic encapsulation of foreign target; and sensory perception of sound. Located in sensory dendrite. Is active in cytosol. Is expressed in embryonic head epidermis; embryonic head sensory system; sense organ; sensory cluster; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in subcortical band heterotopia. Orthologous to several human genes including EML1 (EMAP like 1); EML3 (EMAP like 3); and EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DCX-EMAP in Genome Data Viewer
    Location:
    71A2-71A2; 3-42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14903805..14942907)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14896905..14936007)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45398 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Brother of Bearded A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microtubule-based cytoskeleton is a component of a mechanical signaling pathway in fly campaniform receptors. Liang X, et al. Biophys J, 2014 Dec 16. PMID 25517144, Free PMC Article
    2. NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells. Liang X, et al. Cytoskeleton (Hoboken), 2011 Jan. PMID 21069788, Free PMC Article
    3. A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. Bechstedt S, et al. Nat Commun, 2010 Apr 12. PMID 20975667, Free PMC Article
    4. DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles. Song X, et al. J Cell Biol, 2023 Oct 2. PMID 37651176, Free PMC Article
    5. Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Bardin AJ, et al. Dev Cell, 2006 Feb. PMID 16459303

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles.
      Title: DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule stabilizing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Doublecortin-domain-containing echinoderm-microtubule-associated protein
    Names
    CG42247-PC
    CG42247-PD
    CG42247-PF
    CG42247-PG
    DCX-EMAP-PC
    DCX-EMAP-PD
    DCX-EMAP-PF
    DCX-EMAP-PG
    Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog
    doublecortin
    doublecortin-domain-containing echinoderm-microtubule-associated protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14903805..14942907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274921.1 → NP_001261850.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF94
      Conserved Domains (6) summary
      smart00537
      Location:166 → 253
      DCX; Domain in the Doublecortin (DCX) gene product
      COG2319
      Location:500 → 965
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:446 → 514
      HELP; HELP motif
      sd00039
      Location:673 → 712
      7WD40; WD40 repeat [structural motif]
      cl00155
      Location:300 → 375
      UBQ; Ubiquitin-like proteins
      cl02567
      Location:521 → 911
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_140471.3 → NP_648728.2  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648728.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4IJ53, Q8IGY9, Q9NII4, Q9VUI2, Q9VUI3
      Conserved Domains (6) summary
      smart00537
      Location:166 → 253
      DCX; Domain in the Doublecortin (DCX) gene product
      COG2319
      Location:500 → 965
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:446 → 514
      HELP; HELP motif
      sd00039
      Location:673 → 712
      7WD40; WD40 repeat [structural motif]
      cl00155
      Location:300 → 375
      UBQ; Ubiquitin-like proteins
      cl02567
      Location:521 → 911
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_140472.2 → NP_648729.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VUI3
      Conserved Domains (4) summary
      COG2319
      Location:243 → 708
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:416 → 455
      7WD40; WD40 repeat [structural motif]
      cd17070
      Location:43 → 115
      DCX2_RP_like; Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein
      pfam03451
      Location:189 → 257
      HELP; HELP motif

    4. NM_001274922.1 → NP_001261851.1  Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFN2
      Conserved Domains (4) summary
      COG2319
      Location:275 → 740
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:448 → 487
      7WD40; WD40 repeat [structural motif]
      cd17070
      Location:75 → 147
      DCX2_RP_like; Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein
      pfam03451
      Location:221 → 289
      HELP; HELP motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF94 M9PF94
    M9PFN2 M9PFN2
    Q9VUI3.3 Q9VUI3

    Gene LinkOut

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