CycT Cyclin T [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycTprovided by FlyBase
Official Full Name: Cyclin Tprovided by FlyBase
Primary source: FLYBASE:FBgn0025455
Locus tag: Dmel_CG6292
See related: AllianceGenome:FB:FBgn0025455
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-74EFc; CG6292; Dmcyclin T; Dmel\CG6292; dT; ORE-14; P-TEFb; p124
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in DNA-templated transcription; positive regulation of transcription elongation by RNA polymerase II; and response to heat. Located in nucleus and polytene chromosome puff. Part of P-TEFb complex and super elongation complex. Is expressed in anterior endoderm anlage; dorsal ectoderm anlage; organism; and ventral ectoderm anlage. Orthologous to human CCNT1 (cyclin T1) and CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17551004..17557788, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17544104..17550888, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription, elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in ventral cord development	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of P-TEFb complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin/CDK positive transcription elongation factor complex	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
part_of super elongation complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed

Names: CG6292-PA; CG6292-PB; CG6292-PC; CG6292-PD; CycT-PA; CycT-PB; CycT-PC; CycT-PD; CyclinT; cyclin T1; cyclin T2; dCyclin T; dmCyclin T

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The following sections contain reference sequences that belong to a specific genome build. Explain