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    Vrk3 vaccinia related kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 101568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vrk3provided by MGI
    Official Full Name
    vaccinia related kinase 3provided by MGI
    Primary source
    MGI:MGI:2182465
    See related
    Ensembl:ENSMUSG00000002205 AllianceGenome:MGI:2182465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein phosphatase activator activity and protein phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 35.9), large intestine adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vrk3 in Genome Data Viewer
    Location:
    7 B3; 7 28.9 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44398049..44426939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44748629..44777515)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene zinc finger protein 473 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of tumour progression on the androgenic regulation of the androgen receptor, TRPM-2 and YPT1 genes in the Shionogi carcinoma. Rennie PS, et al. J Steroid Biochem Mol Biol, 1994 Jul. PMID 8049130
    2. Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation. Kang MS, et al. J Exp Med, 2017 Oct 2. PMID 28899869, Free PMC Article
    3. Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells. Park N, et al. Biochem Biophys Res Commun, 2017 May 27. PMID 28412365
    4. Presumed pseudokinase VRK3 functions as a BAF kinase. Park CH, et al. Biochim Biophys Acta, 2015 Jul. PMID 25899223
    5. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. Vega FM, et al. FEBS Lett, 2003 Jun 5. PMID 12782311

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation
      Title: Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation.
    2. Finally, downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells.
      Title: Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells.
    3. These data suggest that VRK3-mediated phosphorylation of BAF may facilitate DNA replication or gene expression by facilitating the dissociation of nuclear envelope proteins and chromatin during interphase.
      Title: Presumed pseudokinase VRK3 functions as a BAF kinase.
    4. various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated vaccinia H1-related (VHR) phosphatase activity
      Title: VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.
    5. VRK genes play a role during embryonic development of hematopoiesis
      Title: Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase VRK3
    Names
    inactive serine/threonine-protein kinase VRK3
    serine/threonine-protein pseudokinase VRK3
    NP_001406082.1
    NP_001406083.1
    NP_001406084.1
    NP_001406085.1
    NP_001406086.1
    NP_001406087.1
    NP_001406088.1
    NP_001406089.1
    NP_598706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419153.1 → NP_001406082.1  serine/threonine-protein kinase VRK3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231

    2. NM_001419154.1 → NP_001406083.1  serine/threonine-protein kinase VRK3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC150895

    3. NM_001419155.1 → NP_001406084.1  serine/threonine-protein kinase VRK3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC150895
      UniProtKB/TrEMBL
      E9PY18
      Related
      ENSMUST00000136069.9

    4. NM_001419156.1 → NP_001406085.1  serine/threonine-protein kinase VRK3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC150895
      UniProtKB/TrEMBL
      E9PY18
      Related
      ENSMUST00000135783.2

    5. NM_001419157.1 → NP_001406086.1  serine/threonine-protein kinase VRK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231
      UniProtKB/Swiss-Prot
      Q8K3G5, Q921W6
      UniProtKB/TrEMBL
      Q3TAR6

    6. NM_001419158.1 → NP_001406087.1  serine/threonine-protein kinase VRK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231
      UniProtKB/Swiss-Prot
      Q8K3G5, Q921W6
      UniProtKB/TrEMBL
      Q3TAR6

    7. NM_001419159.1 → NP_001406088.1  serine/threonine-protein kinase VRK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231
      UniProtKB/Swiss-Prot
      Q8K3G5, Q921W6
      UniProtKB/TrEMBL
      Q3TAR6

    8. NM_001419160.1 → NP_001406089.1  serine/threonine-protein kinase VRK3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC150895
      UniProtKB/TrEMBL
      E9PY18

    9. NM_133945.2 → NP_598706.1  serine/threonine-protein kinase VRK3 isoform 1

      See identical proteins and their annotated locations for NP_598706.1

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231
      Consensus CDS
      CCDS21214.1
      UniProtKB/Swiss-Prot
      Q8K3G5, Q921W6
      UniProtKB/TrEMBL
      Q3TAR6
      Related
      ENSMUSP00000002275.9, ENSMUST00000002275.15
      Conserved Domains (2) summary
      pfam13240
      Location:4 → 26
      zinc_ribbon_2; zinc-ribbon domain
      cl21453
      Location:134 → 436
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_185025.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231
      Related
      ENSMUST00000147952.9

    2. NR_185026.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231

    3. NR_185027.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC150895, AC158231

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44398049..44426939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3G5.2 GenPept UniProtKB/Swiss-Prot:Q8K3G5

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