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    PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009431, updated on 17-Dec-2024

    Summary

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    Gene symbol
    PPM1A
    Gene description
    protein phosphatase, Mg2+/Mn2+ dependent 1A
    See related
    Ensembl:ENSOCUG00000009955
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    PP2Calpha
    Orthologs
    human mouse all
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    Genomic context

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    See PPM1A in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 20 NC_091451.1 (10248940..10301836, complement)
    RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 20 NC_067393.1 (7554540..7605115)

    Chromosome 20 - NC_091451.1Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene ras-related protein Rap-1b-like protein Neighboring gene uncharacterized LOC127484658 Neighboring gene dehydrogenase/reductase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences. Mann DJ, et al. Biochim Biophys Acta, 1992 Feb 28. PMID 1311954
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein phosphatase 1A
    Names
    IA
    PP2C-alpha
    protein phosphatase 2C alpha
    protein phosphatase IA
    NP_001076167.1
    XP_008270039.3
    XP_008270040.1
    XP_008270041.1
    XP_017204831.1
    XP_051681899.2
    XP_069921129.1
    XP_069921130.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082698.1 → NP_001076167.1  protein phosphatase 1A

      See identical proteins and their annotated locations for NP_001076167.1

      Status: PROVISIONAL

      Source sequence(s)
      S87757
      UniProtKB/Swiss-Prot
      P35814
      UniProtKB/TrEMBL
      G1SY94
      Related
      ENSOCUP00000008575.3, ENSOCUT00000009955.3
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 360
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOryCun1.1

    Genomic

    1. NC_091451.1 Reference mOryCun1.1

      Range
      10248940..10301836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051825939.2 → XP_051681899.2  protein phosphatase 1A isoform X2

    2. XM_070065029.1 → XP_069921130.1  protein phosphatase 1A isoform X4

      UniProtKB/TrEMBL
      G1SY94

    3. XM_070065028.1 → XP_069921129.1  protein phosphatase 1A isoform X4

      UniProtKB/TrEMBL
      G1SY94

    4. XM_017349342.3 → XP_017204831.1  protein phosphatase 1A isoform X3

      UniProtKB/TrEMBL
      A0A5F9DI64, G1SY94
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 360
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    5. XM_008271818.4 → XP_008270040.1  protein phosphatase 1A isoform X3

      See identical proteins and their annotated locations for XP_008270040.1

      UniProtKB/TrEMBL
      A0A5F9DI64, G1SY94
      Related
      ENSOCUP00000045068.1
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 360
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    6. XM_008271817.4 → XP_008270039.3  protein phosphatase 1A isoform X1

    7. XM_008271819.4 → XP_008270041.1  protein phosphatase 1A isoform X3

      See identical proteins and their annotated locations for XP_008270041.1

      UniProtKB/TrEMBL
      A0A5F9DI64, G1SY94
      Conserved Domains (2) summary
      cd00143
      Location:23 → 291
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:285 → 360
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35814.1 GenPept UniProtKB/Swiss-Prot:P35814

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