gek genghis khan [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gekprovided by FlyBase
Official Full Name: genghis khanprovided by FlyBase
Primary source: FLYBASE:FBgn0023081
Locus tag: Dmel_CG4012
See related: AllianceGenome:FB:FBgn0023081
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0200864.1; CG4012; Dmel\CG4012; dMRCK; Gek; l(2)09373; MdaPk; Mrck; MRCK; MRCKalpha
Summary: Enables protein kinase activity. Involved in actin polymerization or depolymerization; regulation of actin filament polymerization; and synaptic target recognition. Located in growth cone. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; lamina plexus; medulla; and spermatozoon. Used to study azoospermia. Orthologous to several human genes including CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24092079..24098636, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19979602..19986159, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Genghis khan is required for columnar target specificity in the Drosophila visual system.
Title: The cytoskeletal regulator Genghis khan is required for columnar target specificity in the Drosophila visual system.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed

Names: CG4012-PA; chingis khan; gek-PA; genghis kahn; myotonic dystrophy kinase related

NP_523837.2

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The following sections contain reference sequences that belong to a specific genome build. Explain