Dnah5 dynein, axonemal, heavy chain 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnah5provided by RGD
Official Full Name: dynein, axonemal, heavy chain 5provided by RGD
Primary source: RGD:1560828
See related: EnsemblRapid:ENSRNOG00000048363 AllianceGenome:RGD:1560828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DLP5; Dnahc5; Dnahc8
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and lateral ventricle development. Predicted to be located in 9+0 motile cilium and axoneme. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 42.2), Muscle (RPKM 29.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22

Exon count:: 80

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (80668182..80985918)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (78937788..79255551)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (80947730..81143997) , (81159060..81337560)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the stalk shaft of rat cytoplasmic dynein is an antiparallel alpha-helical coiled coil.
Title: The dynein stalk contains an antiparallel coiled coil with region-specific stability.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049271 (e-PCR)
- UniSTS:145719

AU048434 (e-PCR)
- UniSTS:144884

AF045303 (e-PCR)
- UniSTS:36600

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in lateral ventricle development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lateral ventricle development	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in outer dynein arm assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+0 motile cilium	IEA Inferred from Electronic Annotation more info
located_in 9+0 motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in 9+2 motile cilium	IEA Inferred from Electronic Annotation more info
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
part_of axonemal dynein complex	ISO Inferred from Sequence Orthology more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
part_of outer dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of outer dynein arm	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal heavy chain 5

Names: axonemal beta dynein heavy chain 5; ciliary dynein heavy chain 5; dynein heavy chain 5, axonemal; dynein-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419569.1 → NP_001406498.1 dynein axonemal heavy chain 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6A195, A0A8L2QZ25

Related

ENSRNOP00000085962.1, ENSRNOT00000098157.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

80668182..80985918

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103563.2 → XP_038959491.1 dynein axonemal heavy chain 5 isoform X1

UniProtKB/TrEMBL

A0A8I6G2L4, A0A8L2QZ25

Related

ENSRNOP00000078949.1, ENSRNOT00000101312.2

Conserved Domains (5) summary

COG5245
Location:1625 → 4267

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08385
Location:235 → 787

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1384 → 1789

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1924 → 2251

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:4311 → 4603

Dynein_C; Dynein heavy chain C-terminal domain
XM_063281529.1 → XP_063137599.1 dynein axonemal heavy chain 5 isoform X2

UniProtKB/TrEMBL

A0A8L2QZ25