Naip6 NLR family, apoptosis inhibitory protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Naip6provided by RGD
Full Name: NLR family, apoptosis inhibitory protein 6provided by RGD
Primary source: RGD:621281
See related: EnsemblRapid:ENSRNOG00000033693 AllianceGenome:RGD:621281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Naip; Birc1; Naip2; Birc1a; Birc1b
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase binding activity. Involved in response to amino acid and response to axon injury. Located in perikaryon. Biomarker of brain ischemia. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 304.4), Thymus (RPKM 75.8) and 4 other tissues See more
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Genomic context

Location:: 2q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (33241520..33293184, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (31507423..31559098, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (30377505..30418578, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAIP expression increases in a rat model of liver mass restoration.
Title: NAIP expression increases in a rat model of liver mass restoration.
Results show that inhibition of XIAP or NAIP activity prevents GDNF-mediated neuroprotective effects, suggesting that XIAP and NAIP are essential for intracellular signalling of GDNF in motor neuron survival.
Title: IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo.
Little change in the expression of X-linked inhibitory apoptosis protein mRNA was detected. But using antibody of X-linked inhibitory apoptosis protein, revealed this level of protein was higher in the neonatal motoneurons when compared with the adult.
Title: Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy.
cloning and characterization of cDNA
Title: Cloning and characterization of rat neuronal apoptosis inhibitory protein cDNA.
XIAP up-regulation in response to FSH suppresses granulosa cell apoptosis and facilitates FSH-induced follicular growth.
Title: Involvement of transforming growth factor alpha in the regulation of rat ovarian X-linked inhibitor of apoptosis protein expression and follicular growth by follicle-stimulating hormone.
Multiple, domesticated long terminal repeats (LTRs) of endogenous retroviral elements provide NAIP promoter function in human, mouse, and rat.
Title: Repeated recruitment of LTR retrotransposons as promoters by the anti-apoptotic locus NAIP during mammalian evolution.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Die25 (e-PCR), detects polymorphism
- UniSTS:141911

Birc1b (e-PCR), detects polymorphism
- UniSTS:256359

D2Rat94 (e-PCR)
- UniSTS:118738

RH133013 (e-PCR)
- UniSTS:216296

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of IPAF inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IPAF inflammasome complex	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NLR family, apoptosis inhibitory protein 6

Names: NLR family, apoptosis inhibitory protein 2; baculoviral IAP repeat-containing 1b; baculoviral IAP repeat-containing protein 1b; neuronal apoptosis inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138824.1 → NP_620179.1 NLR family, apoptosis inhibitory protein 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6I587

Related

ENSRNOP00000065975.3, ENSRNOT00000072926.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

33241520..33293184 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760697.4 → XP_008758919.1 NLR family, apoptosis inhibitory protein 6 isoform X1

See identical proteins and their annotated locations for XP_008758919.1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_017591176.3 → XP_017446665.1 NLR family, apoptosis inhibitory protein 6 isoform X1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_008760695.4 → XP_008758917.1 NLR family, apoptosis inhibitory protein 6 isoform X1

See identical proteins and their annotated locations for XP_008758917.1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006231862.5 → XP_006231924.1 NLR family, apoptosis inhibitory protein 6 isoform X1

See identical proteins and their annotated locations for XP_006231924.1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039103479.2 → XP_038959407.1 NLR family, apoptosis inhibitory protein 6 isoform X1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_063281269.1 → XP_063137339.1 NLR family, apoptosis inhibitory protein 6 isoform X1

UniProtKB/TrEMBL

A6I587
XM_006231863.5 → XP_006231925.1 NLR family, apoptosis inhibitory protein 6 isoform X1

See identical proteins and their annotated locations for XP_006231925.1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_063281270.1 → XP_063137340.1 NLR family, apoptosis inhibitory protein 6 isoform X2
XM_017591177.3 → XP_017446666.1 NLR family, apoptosis inhibitory protein 6 isoform X1

UniProtKB/TrEMBL

A6I587, M0R915

Conserved Domains (7) summary

cd00022
Location:61 → 127

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

sd00033
Location:1055 → 1078

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:1157 → 1182

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00653
Location:162 → 228

BIR; Inhibitor of Apoptosis domain

pfam05729
Location:464 → 618

NACHT; NACHT domain

pfam17889
Location:766 → 872

NLRC4_HD; NLRC4 helical domain

cl39015
Location:1080 → 1329

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_063281271.1 → XP_063137341.1 NLR family, apoptosis inhibitory protein 6 isoform X3