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    Surf2 surfeit gene 2 [ Mus musculus (house mouse) ]

    Gene ID: 20931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Surf2provided by MGI
    Official Full Name
    surfeit gene 2provided by MGI
    Primary source
    MGI:MGI:98444
    See related
    Ensembl:ENSMUSG00000014873 AllianceGenome:MGI:98444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf-2
    Summary
    Predicted to be located in nuclear speck; nucleolus; and plasma membrane. Is expressed in embryo. Orthologous to human SURF2 (surfeit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 14.7), liver E14.5 (RPKM 14.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Surf2 in Genome Data Viewer
    Location:
    2 A3; 2 19.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26806420..26810199)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26916372..26920187)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A Neighboring gene predicted gene, 24134 Neighboring gene predicted gene, 57689 Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4, 3'-5' exonuclease Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26819876-26820059

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Williams TJ, et al. Mol Cell Biol, 1986 Dec. PMID 3025660, Free PMC Article
    2. One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes. Huxley C, et al. Mol Cell Biol, 1988 Sep. PMID 3221868, Free PMC Article
    3. Inherited prolonged bleeding time and platelet storage pool deficiency in the subtle gray (sut) mouse. Swank RT, et al. Lab Anim Sci, 1996 Feb. PMID 8699821
    4. The mouse surfeit locus contains a cluster of six genes associated with four CpG-rich islands in 32 kilobases of genomic DNA. Huxley C, et al. Mol Cell Biol, 1990 Feb. PMID 2300057, Free PMC Article
    5. Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus. Giallongo A, et al. Mol Cell Biol, 1989 Jan. PMID 2648130, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    surfeit locus protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421138.1 → NP_001408067.1  surfeit locus protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL773563
      UniProtKB/TrEMBL
      Q3TA91

    2. NM_001421139.1 → NP_001408068.1  surfeit locus protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL773563

    3. NM_001421140.1 → NP_001408069.1  surfeit locus protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773563

    4. NM_001421141.1 → NP_001408070.1  surfeit locus protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773563

    5. NM_013678.4 → NP_038706.1  surfeit locus protein 2 isoform 1

      See identical proteins and their annotated locations for NP_038706.1

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15816.1
      UniProtKB/Swiss-Prot
      P09926
      UniProtKB/TrEMBL
      Q4VAF7
      Related
      ENSMUSP00000015017.8, ENSMUST00000015017.8
      Conserved Domains (1) summary
      pfam05477
      Location:5 → 241
      SURF2; Surfeit locus protein 2 (SURF2)

    RNA

    1. NR_185250.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    2. NR_185251.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    3. NR_185252.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    4. NR_185253.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    5. NR_185254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    6. NR_185255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    7. NR_185256.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26806420..26810199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09926.1 GenPept UniProtKB/Swiss-Prot:P09926

    Gene LinkOut

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