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    Rab29 RAB29, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 226422, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rab29provided by MGI
    Official Full Name
    RAB29, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:2385107
    See related
    Ensembl:ENSMUSG00000026433 AllianceGenome:MGI:2385107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab7l1
    Summary
    Enables GTP binding activity. Involved in cilium assembly and protein localization to ciliary membrane. Acts upstream of or within Golgi organization. Located in Golgi apparatus and vesicle. Orthologous to human RAB29 (RAB29, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.9), subcutaneous fat pad adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab29 in Genome Data Viewer
    Location:
    1 E4; 1 57.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131795004..131801003)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131867210..131872887)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC28972, MGC36539

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation by host of viral process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to ciliary membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of retrograde transport, endosome to Golgi NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in vacuole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-7L1
    Names
    RAB7, member RAS oncogene family-like 1
    rab-7-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421410.1NP_001408339.1  ras-related protein Rab-7L1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161805
      UniProtKB/TrEMBL
      E9QLQ7
      Related
      ENSMUSP00000108005.2, ENSMUST00000112386.8
    2. NM_001421411.1NP_001408340.1  ras-related protein Rab-7L1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161805
    3. NM_001421412.1NP_001408341.1  ras-related protein Rab-7L1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161805
    4. NM_001421413.1NP_001408342.1  ras-related protein Rab-7L1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161805
    5. NM_001421414.1NP_001408343.1  ras-related protein Rab-7L1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161805
      UniProtKB/TrEMBL
      E9QLQ7
    6. NM_144875.3NP_659124.2  ras-related protein Rab-7L1 isoform 1

      See identical proteins and their annotated locations for NP_659124.2

      Status: VALIDATED

      Source sequence(s)
      AC161805
      Consensus CDS
      CCDS15276.1
      UniProtKB/TrEMBL
      E9QLQ7
      Related
      ENSMUSP00000027693.8, ENSMUST00000027693.8
      Conserved Domains (2) summary
      smart00175
      Location:8176
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:8204
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    RNA

    1. NR_185300.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161805
    2. NR_185301.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161805

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131795004..131801003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)