SIN3 transcriptional regulator SIN3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SIN3
Official Full Name: transcriptional regulator SIN3
Primary source: SGD:S000005364
Locus tag: YOL004W
See related: AllianceGenome:SGD:S000005364; FungiDB:YOL004W; VEuPathDB:YOL004W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CPE1; GAM2; RPD1; SDI1; SDS16; UME4
Summary: Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including G2/M transition of mitotic cell cycle; rDNA chromatin condensation; and regulation of macromolecule metabolic process. Part of Rpd3L complex and Rpd3S complex. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SIN3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (316938..321548)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.
Title: Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.
Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
Title: Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.
Title: Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.
Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
Title: Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
Title: Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
corepressors may be recruited not only by repressors but also by activators such as Ino2. Indeed, we could demonstrate direct interaction of Ino2 with Sin3 and Cyc8. The Opi1 repressor interaction domain within Ino2 is also able to contact Sin3 and Cyc8.
Title: Promoter recruitment of corepressors Sin3 and Cyc8 by activator proteins of the yeast Saccharomyces cerevisiae.
We also present evidence that indicates Rim11/Ume6 works independently but in parallel with that of checkpoint inhibition, dNTP regulation, and sister-chromatid recombination. In conclusion, our results establish Rim11, Ume6, the histone deacetylase complex Sin3-Rpd3 and Sml1 as new factors important in the events of faulty lagging strand synthesis.
Title: GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.
Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation.
Title: Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.
These results show that the sin3 mutation decreases both spontaneous and UV-induced levels of levels.
Title: [Control levels of Sin3 histone deacetylase for spontaneous and UV-induced mutagenesis in yeasts Saccharomyces cerevisiae].
Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels
Title: Ume6 transcription factor is part of a signaling cascade that regulates autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of rDNA heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA chromatin condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Rpd3L complex	HDA more info	PubMed
part_of Rpd3L complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rpd3L-Expanded complex	HDA more info	PubMed
part_of Rpd3S complex	IDA Inferred from Direct Assay more info	PubMed
part_of Sin3-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sin3-type complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcriptional regulator SIN3

NP_014639.1

Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

316938..321548

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183258.1 → NP_014639.1 TPA: transcriptional regulator SIN3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W263, P22579, Q08049

UniProtKB/TrEMBL

A6ZNK2, C7GJV6

Conserved Domains (4) summary

COG5602
Location:75 → 1493

Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

pfam02671
Location:240 → 284

PAH; Paired amphipathic helix repeat

pfam08295
Location:749 → 844

Sin3_corepress; Sin3 family co-repressor

pfam16879
Location:1138 → 1410

Sin3a_C; C-terminal domain of Sin3a protein