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    Slc43a3 solute carrier family 43, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 58207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc43a3provided by MGI
    Official Full Name
    solute carrier family 43, member 3provided by MGI
    Primary source
    MGI:MGI:1931054
    See related
    Ensembl:ENSMUSG00000027074 AllianceGenome:MGI:1931054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eeg1; SEEEG-1
    Summary
    Enables fatty acid transmembrane transporter activity. Predicted to be involved in hypoxanthine transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including adrenal gland; cardiovascular system; central nervous system; genitourinary system; and gut. Orthologous to human SLC43A3 (solute carrier family 43 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 98.4), liver E14.5 (RPKM 73.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc43a3 in Genome Data Viewer
    Location:
    2 D; 2 49.45 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84766943..84788853)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84936545..84958509)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D930003E18 gene Neighboring gene solute carrier family 43, member 1 Neighboring gene reticulon 4 receptor-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8789 Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene STARR-positive B cell enhancer ABC_E7835 Neighboring gene STARR-positive B cell enhancer ABC_E7836 Neighboring gene STARR-positive B cell enhancer ABC_E11145 Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 2, bone marrow Neighboring gene proteoglycan 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional comparison of human and murine equilibrative nucleobase transporter 1. Kim CS, et al. PLoS One, 2024. PMID 39361655, Free PMC Article
    2. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. Stuart RO, et al. Am J Physiol Renal Physiol, 2001 Dec. PMID 11704567
    3. Slc43a3 is a regulator of free fatty acid flux. Hasbargen KB, et al. J Lipid Res, 2020 May. PMID 32217606, Free PMC Article
    4. Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Furukawa J, et al. Sci Rep, 2015 Oct 12. PMID 26455426, Free PMC Article
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional comparison of human and murine equilibrative nucleobase transporter 1.
      Title: Functional comparison of human and murine equilibrative nucleobase transporter 1.
    2. Slc43a3 is a regulator of free fatty acid flux.
      Title: Slc43a3 is a regulator of free fatty acid flux.
    3. SLC43A3 is an equilibrative nucleobase transporter involved in purine salvage in mammals.
      Title: Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC107644

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in guanine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hypoxanthine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hypoxanthine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    equilibrative nucleobase transporter 1
    Names
    embryonic epithelia gene 1 protein
    embryonic epithelial gene 1
    selectively expressed in embryonic epithelia protein-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421858.1 → NP_001408787.1  equilibrative nucleobase transporter 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935159
      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

    2. NM_001421859.1 → NP_001408788.1  equilibrative nucleobase transporter 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935159
      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

    3. NM_001421860.1 → NP_001408789.1  equilibrative nucleobase transporter 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935159
      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

    4. NM_001421861.1 → NP_001408790.1  equilibrative nucleobase transporter 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL935159
      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

    5. NM_001421862.1 → NP_001408791.1  equilibrative nucleobase transporter 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL935159

    6. NM_001421863.1 → NP_001408792.1  equilibrative nucleobase transporter 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL935159

    7. NM_001421864.1 → NP_001408793.1  equilibrative nucleobase transporter 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL935159

    8. NM_001421865.1 → NP_001408794.1  equilibrative nucleobase transporter 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL935159

    9. NM_001421866.1 → NP_001408795.1  equilibrative nucleobase transporter 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL935159

    10. NM_001421867.1 → NP_001408796.1  equilibrative nucleobase transporter 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL935159

    11. NM_001421868.1 → NP_001408797.1  equilibrative nucleobase transporter 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL935159

    12. NM_001421869.1 → NP_001408798.1  equilibrative nucleobase transporter 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL935159

    13. NM_001421870.1 → NP_001408799.1  equilibrative nucleobase transporter 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL935159

    14. NM_021398.4 → NP_067373.2  equilibrative nucleobase transporter 1 isoform a

      See identical proteins and their annotated locations for NP_067373.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AL935159
      Consensus CDS
      CCDS38164.1
      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
      Related
      ENSMUSP00000088227.6, ENSMUST00000090726.6
      Conserved Domains (1) summary
      TIGR00893
      Location:62 → 195
      2A0114; D-galactonate transporter

    RNA

    1. NR_185338.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    2. NR_185339.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    3. NR_185340.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    4. NR_185341.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    5. NR_185342.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    6. NR_185343.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    7. NR_185344.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    8. NR_185345.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    9. NR_185346.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    10. NR_185347.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL935159

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84766943..84788853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499958.4 → XP_006500021.1  equilibrative nucleobase transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006500021.1

      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
      Conserved Domains (1) summary
      TIGR00893
      Location:62 → 195
      2A0114; D-galactonate transporter

    2. XM_006499957.3 → XP_006500020.1  equilibrative nucleobase transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006500020.1

      UniProtKB/Swiss-Prot
      A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
      Conserved Domains (1) summary
      TIGR00893
      Location:62 → 195
      2A0114; D-galactonate transporter

    3. XM_011239719.4 → XP_011238021.1  equilibrative nucleobase transporter 1 isoform X2

      Conserved Domains (1) summary
      TIGR00893
      Location:62 → 195
      2A0114; D-galactonate transporter

    RNA

    1. XR_003953681.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AVZ9.1 GenPept UniProtKB/Swiss-Prot:A2AVZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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