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    htp-1 HORMA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 259571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    htp-1
    Official Full Name
    HORMA domain-containing protein
    Primary source
    WormBase:WBGene00002032
    Locus tag
    CELE_F41H10.10
    See related
    AllianceGenome:WB:WBGene00002032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of centriole-centriole cohesion. Located in lateral element. Is expressed in Z2 and Z3. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See htp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (5390189..5391557, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Long chain fatty acid elongase 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ER membrane protein complex subunit 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion. Martinez-Perez E, et al. Genes Dev, 2008 Oct 15. PMID 18923085, Free PMC Article
    2. The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression. Silva N, et al. Dev Cell, 2014 Nov 24. PMID 25455309
    3. Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. Sato-Carlton A, et al. PLoS Genet, 2020 Nov. PMID 33175901, Free PMC Article
    4. HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis. Martinez-Perez E, et al. Genes Dev, 2005 Nov 15. PMID 16291646, Free PMC Article
    5. The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. Russo AE, et al. PLoS Genet, 2023 Apr. PMID 37058535, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
      Title: ERK phosphorylates chromosomal axis component HORMA domain protein HTP-1 to regulate oocyte numbers.
    2. Block III (21 RNAs) was enriched for RNA-binding proteins, including previously validated FBF targets gld-1 and htp-1 We suggest that Block I RNAs belong to the FBF network for spermatogenesis, and that Blocks II and III are associated with stem cell functions.
      Title: Toward Identifying Subnetworks from FBF Binding Landscapes in Caenorhabditis Spermatogenic or Oogenic Germlines.
    3. HTP-1 functionally couples homolog alignment to its stabilization by synapsis by preventing the association of synaptonemal complex (SC) components with unaligned and immature chromosome axes
      Title: HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans.
    4. A model is proposed in which HTP-1 functions to establish or maintain multiple constraints that operate to ensure coordination of events leading to a successful outcome of meiotic prophase (chiasma formation)
      Title: HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of centriole-centriole cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HORMA domain-containing protein
    NP_500799.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5390189..5391557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068398.5 → NP_500799.2  HORMA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500799.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20305
      Conserved Domains (1) summary
      pfam02301
      Location:38 → 240
      HORMA; HORMA domain
    Nucleotide Protein
    Heading Accession and Version

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