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    Evl Ena-vasodilator stimulated phosphoprotein [ Mus musculus (house mouse) ]

    Gene ID: 14026, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Evlprovided by MGI
    Official Full Name
    Ena-vasodilator stimulated phosphoproteinprovided by MGI
    Primary source
    MGI:MGI:1194884
    See related
    Ensembl:ENSMUSG00000021262 AllianceGenome:MGI:1194884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b2600Clo
    Summary
    Enables SH3 domain binding activity and profilin binding activity. Involved in actin polymerization or depolymerization and positive regulation of actin filament polymerization. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion; lamellipodium; and phagocytic vesicle. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 64.8), CNS E14 (RPKM 64.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Evl in Genome Data Viewer
    Location:
    12 F1; 12 59.46 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108520942..108654775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108554681..108688516)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene echinoderm microtubule associated protein like 1 Neighboring gene bridging integrator 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33243 Neighboring gene predicted gene, 16596 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109869753-109869906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109873778-109874013 Neighboring gene predicted gene, 53766 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109924618-109924819 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109924858-109925011 Neighboring gene microRNA 342 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109939490-109939738 Neighboring gene predicted gene, 33467 Neighboring gene delta 4-desaturase, sphingolipid 2 Neighboring gene predicted gene, 40572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. Zink J, et al. EMBO Rep, 2021 Feb 3. PMID 33512764, Free PMC Article
    2. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function. Fedorov AA, et al. Nat Struct Biol, 1999 Jul. PMID 10404224
    3. Ena/VASP proteins regulate cortical neuronal positioning. Goh KL, et al. Curr Biol, 2002 Apr 2. PMID 11937025
    4. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8(+) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Waldman MM, et al. Front Immunol, 2022. PMID 35757762, Free PMC Article
    5. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. Laurent V, et al. J Cell Biol, 1999 Mar 22. PMID 10087267, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
      Title: EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.
    2. EVL selectively mediate activated T-cell trafficking by promoting the diapedesis step of transendothelial migration in a alpha4 integrin-dependent manner.
      Title: Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration.
    3. Thus, unlike host proteins characterized in Shigella pathogenesis that promote bacterial spread, VASP and EVL function to limit it.
      Title: Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery.
    4. Altogether these observations demonstrate that ENA/VASP proteins are implicated in the establishment and maintenance of the axonal structure and that a change on their expression levels triggers neuronal degeneration.
      Title: ENA/VASP downregulation triggers cell death by impairing axonal maintenance in hippocampal neurons.
    5. Ena-vasp is required for endothelial barrier function in vivo.
      Title: Ena/VASP is required for endothelial barrier function in vivo.
    6. Ena/VASP proteins regulate cortical neuronal positioning.
      Title: Ena/VASP proteins regulate cortical neuronal positioning.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables profilin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament-based movement NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in actin nucleation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ena/VASP-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163394.1 → NP_001156866.1  ena/VASP-like protein isoform 1

      See identical proteins and their annotated locations for NP_001156866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC059810, BC096017
      Consensus CDS
      CCDS49167.1
      UniProtKB/Swiss-Prot
      P70429, Q9ERU8
      UniProtKB/TrEMBL
      Q6PB99
      Related
      ENSMUSP00000021689.7, ENSMUST00000021689.14
      Conserved Domains (2) summary
      cd01207
      Location:5 → 113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:377 → 409
      VASP_tetra; VASP tetramerisation domain

    2. NM_001163395.1 → NP_001156867.1  ena/VASP-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' coding region, uses a downstream start codon, and lacks an in-frame exon in the 3' coding region, compared to isoform 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK134563, BC059810
      Consensus CDS
      CCDS49168.1
      UniProtKB/TrEMBL
      F8WJB9, Q6PB99
      Related
      ENSMUSP00000105480.3, ENSMUST00000109854.9
      Conserved Domains (2) summary
      cd01207
      Location:11 → 119
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:362 → 394
      VASP_tetra; VASP tetramerisation domain

    3. NM_001163396.2 → NP_001156868.1  ena/VASP-like protein isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AK134563, AK151633, BC059810
      Consensus CDS
      CCDS49169.1
      UniProtKB/TrEMBL
      E9PVP4, Q6PB99
      Related
      ENSMUSP00000133072.2, ENSMUST00000172409.2
      Conserved Domains (2) summary
      cd01207
      Location:1 → 100
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:364 → 396
      VASP_tetra; VASP tetramerization domain

    4. NM_001422023.1 → NP_001408952.1  ena/VASP-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC137155, AC139568, AC152061
      UniProtKB/TrEMBL
      F8WJB9

    5. NM_007965.3 → NP_031991.3  ena/VASP-like protein isoform 2

      See identical proteins and their annotated locations for NP_031991.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      BC059810, BC096017
      Consensus CDS
      CCDS26161.1
      UniProtKB/TrEMBL
      Q6PB99
      Related
      ENSMUSP00000076916.6, ENSMUST00000077735.13
      Conserved Domains (2) summary
      cd01207
      Location:5 → 113
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:356 → 388
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108520942..108654775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515470.3 → XP_006515533.1  ena/VASP-like protein isoform X1

      UniProtKB/TrEMBL
      Q6PB99
      Conserved Domains (2) summary
      cd01207
      Location:11 → 119
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:383 → 415
      VASP_tetra; VASP tetramerisation domain

    2. XM_006515471.3 → XP_006515534.1  ena/VASP-like protein isoform X2

      UniProtKB/TrEMBL
      Q6PB99
      Related
      ENSMUSP00000152364.2, ENSMUST00000223109.2
      Conserved Domains (2) summary
      cd01207
      Location:7 → 115
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:379 → 411
      VASP_tetra; VASP tetramerisation domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70429.2 GenPept UniProtKB/Swiss-Prot:P70429

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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