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    Syn3 synapsin III [ Mus musculus (house mouse) ]

    Gene ID: 27204, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Syn3provided by MGI
    Official Full Name
    synapsin IIIprovided by MGI
    Primary source
    MGI:MGI:1351334
    See related
    Ensembl:ENSMUSG00000059602 AllianceGenome:MGI:1351334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP binding activity. Involved in synaptic vesicle clustering. Located in postsynaptic density and synaptic vesicle membrane. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skeletal muscle. Used to study autism spectrum disorder and epilepsy. Orthologous to human SYN3 (synapsin III). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 3.6), whole brain E14.5 (RPKM 2.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syn3 in Genome Data Viewer
    Location:
    10 C1; 10 41.95 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85884610..86336730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86048746..86498926, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27455 Neighboring gene BPI fold containing family C Neighboring gene STARR-positive B cell enhancer ABC_E8355 Neighboring gene F-box protein 7 Neighboring gene predicted gene, 24430 Neighboring gene RIKEN cDNA 4930486F22 gene Neighboring gene STARR-seq mESC enhancer starr_27456 Neighboring gene predicted gene, 51812 Neighboring gene STARR-seq mESC enhancer starr_27457 Neighboring gene STARR-seq mESC enhancer starr_27458 Neighboring gene predicted gene, 35636 Neighboring gene STARR-seq mESC enhancer starr_27459 Neighboring gene VISTA enhancer mm52 Neighboring gene predicted gene, 57766 Neighboring gene tissue inhibitor of metalloproteinase 3 Neighboring gene STARR-seq mESC enhancer starr_27465 Neighboring gene predicted gene 6729 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance. Moore A, et al. eNeuro, 2021 Sep-Oct. PMID 34413083, Free PMC Article
    2. Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation. Piccini A, et al. J Neurosci, 2015 Sep 23. PMID 26400944, Free PMC Article
    3. Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype. Faustini G, et al. Mol Ther, 2022 Apr 6. PMID 35038583, Free PMC Article
    4. Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear. Porton B, et al. Genes Brain Behav, 2010 Apr. PMID 20050925, Free PMC Article
    5. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. Kao HT, et al. J Comp Neurol, 2008 Apr 20. PMID 18271024

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLCgamma1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
      Title: PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III.
    2. Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.
      Title: Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.
    3. Syn III constitutes a crucial mediator of alpha-synuclein aggregation and toxicity and identify Syn III as a novel therapeutic target for Parkinson's disease
      Title: Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.
    4. This study demonstrated that synapsin 3 regulating GABA Release from Hippocampal Interneurons.
      Title: Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.
    5. These findings support a reciprocal modulatory interaction of alpha-syn and synapsin III in the regulation of dopamine neuron synaptic function.
      Title: α-synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons.
    6. The results of this study show SynIII plays a central role in early stages of neuronal development involving phosphorylation-dependent neuronal survival, polarization, and neuritic growth
      Title: Phosphorylation by PKA and Cdk5 Mediates the Early Effects of Synapsin III in Neuronal Morphological Maturation.
    7. This study demonostrated that Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.
      Title: Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.
    8. Behavioral and neurophysiological features of Syn3 knockout mice are characterized by observation of the development and progress of seizures from postnatal day 20 to 180.
      Title: Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice.
    9. Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
      Title: Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
    10. Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear
      Title: Mice lacking synapsin III show abnormalities in explicit memory and conditioned fear.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130403

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle clustering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synapsin-3
    Names
    synapsin IIIa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164495.1 → NP_001157967.1  synapsin-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (2) is shorter and has a unique C-terminus, compared to isoform 1.
      Source sequence(s)
      AC125060, AK043854, AK084032
      Consensus CDS
      CCDS48659.1
      UniProtKB/TrEMBL
      D3Z620
      Related
      ENSMUSP00000113408.2, ENSMUST00000121789.2
      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 236
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    2. NM_013722.3 → NP_038750.2  synapsin-3 isoform 1

      See identical proteins and their annotated locations for NP_038750.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122919, AK043854, AK080557, BC059894, BC107397
      Consensus CDS
      CCDS24096.1
      UniProtKB/Swiss-Prot
      E9QNQ6, Q8JZP2
      UniProtKB/TrEMBL
      Q3KN99, Q9QZA3
      Related
      ENSMUSP00000113720.2, ENSMUST00000120638.8
      Conserved Domains (4) summary
      pfam02750
      Location:192 → 394
      Synapsin_C; Synapsin, ATP binding domain
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam09770
      Location:400 → 534
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      85884610..86336730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513698.4 → XP_006513761.1  synapsin-3 isoform X1

      See identical proteins and their annotated locations for XP_006513761.1

      UniProtKB/Swiss-Prot
      E9QNQ6, Q8JZP2
      UniProtKB/TrEMBL
      Q3KN99, Q9QZA3
      Conserved Domains (4) summary
      pfam02750
      Location:192 → 394
      Synapsin_C; Synapsin, ATP binding domain
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam09770
      Location:400 → 534
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal

    2. XM_006513699.5 → XP_006513762.1  synapsin-3 isoform X1

      See identical proteins and their annotated locations for XP_006513762.1

      UniProtKB/Swiss-Prot
      E9QNQ6, Q8JZP2
      UniProtKB/TrEMBL
      Q3KN99, Q9QZA3
      Conserved Domains (4) summary
      pfam02750
      Location:192 → 394
      Synapsin_C; Synapsin, ATP binding domain
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam09770
      Location:400 → 534
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal

    3. XM_006513700.5 → XP_006513763.1  synapsin-3 isoform X1

      See identical proteins and their annotated locations for XP_006513763.1

      UniProtKB/Swiss-Prot
      E9QNQ6, Q8JZP2
      UniProtKB/TrEMBL
      Q3KN99, Q9QZA3
      Conserved Domains (4) summary
      pfam02750
      Location:192 → 394
      Synapsin_C; Synapsin, ATP binding domain
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam09770
      Location:400 → 534
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal

    4. XM_030245098.2 → XP_030100958.1  synapsin-3 isoform X2

      Conserved Domains (3) summary
      pfam02078
      Location:90 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 307
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    5. XM_036155797.1 → XP_036011690.1  synapsin-3 isoform X2

      Conserved Domains (3) summary
      pfam02078
      Location:90 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 307
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    6. XM_030245101.2 → XP_030100961.1  synapsin-3 isoform X5

      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 257
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    7. XM_030245100.2 → XP_030100960.1  synapsin-3 isoform X4

      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 236
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    8. XM_030245103.2 → XP_030100963.1  synapsin-3 isoform X7

      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 236
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    9. XM_030245099.2 → XP_030100959.1  synapsin-3 isoform X3

      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 236
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    10. XM_030245102.2 → XP_030100962.1  synapsin-3 isoform X6

      UniProtKB/TrEMBL
      D3Z620
      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 236
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    11. XM_030245104.2 → XP_030100964.1  synapsin-3 isoform X8

      Conserved Domains (3) summary
      pfam02078
      Location:93 → 190
      Synapsin; N-terminal domain
      pfam10581
      Location:1 → 29
      Synapsin_N; Synapsin N-terminal
      cl17255
      Location:192 → 239
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZP2.2 GenPept UniProtKB/Swiss-Prot:Q8JZP2

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