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    TTLL3B Tubulin tyrosine ligase-like 3B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33946, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TTLL3Bprovided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 3Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031853
    Locus tag
    Dmel_CG11201
    See related
    AllianceGenome:FB:FBgn0031853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11201; DmCG11201; Dmel\CG11201; dmTTLL3B; TTLL3
    Summary
    Enables protein-glycine ligase activity, elongating and protein-glycine ligase activity, initiating. Involved in axoneme assembly; protein polyglycylation; and sperm individualization. Located in axoneme; microtubule cytoskeleton; and nucleus. Orthologous to human TTLL8 (tubulin tyrosine ligase like 8). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See TTLL3B in Genome Data Viewer
    Location:
    27A2-27A2; 2-22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6732866..6736149)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6732866..6736149)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene homer Neighboring gene Liprin-alpha Neighboring gene Tubulin tyrosine ligase-like 3A Neighboring gene meng-po Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis. Lécureuil C, et al. BMC Ecol Evol, 2021 May 19. PMID 34011283, Free PMC Article
    2. Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules. Mendes Maia T, et al. Biol Open, 2014 Feb 15. PMID 24414207, Free PMC Article
    3. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Rogowski K, et al. Cell, 2009 Jun 12. PMID 19524510
    4. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    5. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, elongating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glycine ligase activity, initiating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glycine ligase activity, initiating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tubulin tyrosine ligase-like 3B
    Names
    CG11201-PB
    TTLL3B-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6732866..6736149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135224.3 → NP_609068.2  tubulin tyrosine ligase-like 3B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609068.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BHY1, Q9VM92
      Conserved Domains (1) summary
      pfam03133
      Location:325 → 626
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM92.2 Q9VM92

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