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    Lcp1 lymphocyte cytosolic protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 18826, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lcp1provided by MGI
    Official Full Name
    lymphocyte cytosolic protein 1provided by MGI
    Primary source
    MGI:MGI:104808
    See related
    Ensembl:ENSMUSG00000021998 AllianceGenome:MGI:104808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pls2; pp65; LCP-1; D14Ertd310e
    Summary
    Enables actin filament binding activity. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament; phagocytic cup; and ruffle. Is expressed in several structures, including brain; cardiovascular system; female reproductive system; gut; and yolk sac. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 28.5), spleen adult (RPKM 23.6) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Lcp1 in Genome Data Viewer
    Location:
    14 D3; 14 39.63 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75368570..75468282)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75131105..75230842)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RUN and cysteine rich domain containing beclin 1 interacting protein like Neighboring gene predicted gene, 57618 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75456661-75456962 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75460374-75460674 Neighboring gene STARR-seq mESC enhancer starr_37135 Neighboring gene leucine rich repeat containing 63 Neighboring gene predicted gene 15628 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75576489-75576789 Neighboring gene STARR-seq mESC enhancer starr_37136 Neighboring gene STARR-positive B cell enhancer ABC_E4120 Neighboring gene STARR-positive B cell enhancer ABC_E8899 Neighboring gene STARR-positive B cell enhancer ABC_E7338 Neighboring gene carboxypeptidase B2 Neighboring gene predicted gene, 35679 Neighboring gene STARR-positive B cell enhancer ABC_E7339 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37139 Neighboring gene zinc finger CCCH type containing 13 Neighboring gene predicted gene, 46470

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding  
    enables GTPase binding  
    enables actin filament binding  
    enables actin filament binding PubMed 
    enables actin filament binding  
    enables calcium ion binding  
    enables integrin binding  
    enables integrin binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response  
    involved_in T cell activation involved in immune response  
    involved_in actin filament bundle assembly  
    acts_upstream_of_or_within actin filament bundle assembly PubMed 
    involved_in actin filament bundle assembly  
    involved_in actin filament network formation  
    involved_in animal organ regeneration  
    involved_in cell migration  
    involved_in cell migration  
    involved_in extracellular matrix disassembly  
    involved_in extracellular matrix disassembly  
    involved_in positive regulation of podosome assembly  
    involved_in positive regulation of podosome assembly  
    involved_in protein kinase A signaling  
    involved_in protein kinase A signaling  
    involved_in regulation of intracellular protein transport  
    involved_in regulation of intracellular protein transport  
    acts_upstream_of_or_within response to wounding  
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in actin cytoskeleton PubMed 
    located_in actin cytoskeleton  
    is_active_in actin filament  
    located_in actin filament PubMed 
    located_in actin filament  
    is_active_in actin filament bundle  
    located_in actin filament bundle  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in filopodium  
    located_in filopodium  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in glial cell projection PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in phagocytic cup PubMed 
    located_in plasma membrane  
    located_in podosome  
    located_in podosome  
    located_in ruffle PubMed 
    located_in ruffle  
    located_in ruffle membrane  
    located_in stress fiber  
    colocalizes_with stress fiber  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    plastin-2
    Names
    65 kDa macrophage protein
    L-fimbrin
    L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
    plastin 2, L

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001247984.2NP_001234913.1  plastin-2

      See identical proteins and their annotated locations for NP_001234913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC129591, AC161877
      Consensus CDS
      CCDS27276.1
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
      Related
      ENSMUSP00000121201.2, ENSMUST00000124499.8
      Conserved Domains (5) summary
      cd00051
      Location:1379
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:98242
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21327
      Location:251375
      CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
      cd21333
      Location:511625
      CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
      cl00030
      Location:374507
      CH_SF; calponin homology (CH) domain superfamily
    2. NM_001424512.1NP_001411441.1  plastin-2

      Status: VALIDATED

      Source sequence(s)
      AC129591, AC161877
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
      Related
      ENSMUSP00000117137.2, ENSMUST00000131802.2
    3. NM_001424513.1NP_001411442.1  plastin-2

      Status: VALIDATED

      Source sequence(s)
      AC129591, AC161877
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
    4. NM_001424514.1NP_001411443.1  plastin-2

      Status: VALIDATED

      Source sequence(s)
      AC129591, AC161877
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
    5. NM_001424515.1NP_001411444.1  plastin-2

      Status: VALIDATED

      Source sequence(s)
      AC129591, AC161877
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
    6. NM_008879.5NP_032905.2  plastin-2

      See identical proteins and their annotated locations for NP_032905.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC129591, AC161877
      Consensus CDS
      CCDS27276.1
      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
      Related
      ENSMUSP00000116271.2, ENSMUST00000145303.8
      Conserved Domains (5) summary
      cd00051
      Location:1379
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:98242
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21327
      Location:251375
      CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
      cd21333
      Location:511625
      CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
      cl00030
      Location:374507
      CH_SF; calponin homology (CH) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      75368570..75468282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158507.1XP_036014400.1  plastin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UE24, Q61233, Q8R1X3, Q9CV77
      UniProtKB/TrEMBL
      Q3TJX0, Q3U6Z1, Q3U9M7
      Conserved Domains (5) summary
      cd00051
      Location:1379
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd21292
      Location:98242
      CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
      cd21327
      Location:251375
      CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
      cd21333
      Location:511625
      CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
      cl00030
      Location:374507
      CH_SF; calponin homology (CH) domain superfamily
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