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    FGFR3 fibroblast growth factor receptor 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281769, updated on 1-Jan-2025

    Summary

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    Official Symbol
    FGFR3provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 3provided by VGNC
    Primary source
    VGNC:VGNC:50180
    See related
    Ensembl:ENSBTAG00000007164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (116766308..116781167, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 23 Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene transforming acidic coiled-coil containing protein 3 Neighboring gene transmembrane protein 129, E3 ubiquitin ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull. Häfliger IM, et al. Anim Genet, 2020 Jun. PMID 32239744
    2. Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3. Degnin CR, et al. Mol Biol Cell, 2011 Oct. PMID 21865593, Free PMC Article
    3. The bovine fibroblast growth factor receptor 3 (FGFR3) gene is not the locus responsible for bovine chondrodysplastic dwarfism in Japanese brown cattle. Takami M, et al. Anim Genet, 2002 Oct. PMID 12354143
    4. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Campos DB, et al. Genet Mol Res, 2010 Feb 23. PMID 20198587
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull.
      Title: De novo stop-lost germline mutation in FGFR3 causes severe chondrodysplasia in the progeny of a Holstein bull.
    2. The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.
      Title: Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3.
    3. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
      Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
    4. chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene
      Title: The bovine fibroblast growth factor receptor 3 (FGFR3) gene is not the locus responsible for bovine chondrodysplastic dwarfism in Japanese brown cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 3
    Names
    fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)
    NP_776743.1
    XP_024848758.1
    XP_024848759.1
    XP_024848761.1
    XP_024848762.1
    XP_024848764.1
    XP_024848765.1
    XP_024848767.1
    XP_059743299.1
    XP_059743300.1
    XP_059743301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174318.3 → NP_776743.1  fibroblast growth factor receptor 3 precursor

      See identical proteins and their annotated locations for NP_776743.1

      Status: VALIDATED

      Source sequence(s)
      AB059430
      UniProtKB/TrEMBL
      F6PVB0, Q95M13
      Related
      ENSBTAP00000064396.2, ENSBTAT00000075084.2
      Conserved Domains (4) summary
      cd05857
      Location:157 → 241
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:264 → 353
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:52 → 109
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:455 → 788
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      116766308..116781167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024992997.2 → XP_024848765.1  fibroblast growth factor receptor 3 isoform X7

      UniProtKB/TrEMBL
      F6PVB0
      Conserved Domains (4) summary
      cd05857
      Location:157 → 241
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:264 → 353
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:52 → 109
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:456 → 789
      PKc_like; Protein Kinases, catalytic domain

    2. XM_024992996.2 → XP_024848764.1  fibroblast growth factor receptor 3 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MPT9
      Related
      ENSBTAP00000073540.2, ENSBTAT00000086336.2
      Conserved Domains (4) summary
      cd05857
      Location:157 → 241
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:52 → 109
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:264 → 351
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cl21453
      Location:457 → 790
      PKc_like; Protein Kinases, catalytic domain

    3. XM_059887316.1 → XP_059743299.1  fibroblast growth factor receptor 3 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MPT9

    4. XM_024992999.2 → XP_024848767.1  fibroblast growth factor receptor 3 isoform X8

      UniProtKB/TrEMBL
      F6PVB0, Q95M13
      Conserved Domains (4) summary
      cd05857
      Location:157 → 241
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:264 → 353
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:52 → 109
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:455 → 788
      PKc_like; Protein Kinases, catalytic domain

    5. XM_059887318.1 → XP_059743301.1  fibroblast growth factor receptor 3 isoform X10

      UniProtKB/TrEMBL
      A0A3Q1M2X7

    6. XM_059887317.1 → XP_059743300.1  fibroblast growth factor receptor 3 isoform X9

      UniProtKB/TrEMBL
      A0A3Q1MPT9

    7. XM_024992990.2 → XP_024848758.1  fibroblast growth factor receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MPT9
      Conserved Domains (4) summary
      cd05857
      Location:167 → 251
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:62 → 119
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:274 → 361
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cl21453
      Location:468 → 801
      PKc_like; Protein Kinases, catalytic domain

    8. XM_024992993.2 → XP_024848761.1  fibroblast growth factor receptor 3 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M2X7
      Conserved Domains (4) summary
      cd05857
      Location:167 → 251
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:274 → 363
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:62 → 119
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:466 → 799
      PKc_like; Protein Kinases, catalytic domain

    9. XM_024992991.2 → XP_024848759.1  fibroblast growth factor receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MPT9
      Conserved Domains (4) summary
      cd05857
      Location:167 → 251
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:62 → 119
      IGc2; Immunoglobulin C-2 Type
      cd04974
      Location:274 → 361
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cl21453
      Location:467 → 800
      PKc_like; Protein Kinases, catalytic domain

    10. XM_024992994.2 → XP_024848762.1  fibroblast growth factor receptor 3 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M2X7, A0AAA9RXW6
      Related
      ENSBTAP00000076064.1, ENSBTAT00000129080.1
      Conserved Domains (4) summary
      cd05857
      Location:167 → 251
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:274 → 363
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:62 → 119
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:465 → 798
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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