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    Fam185a family with sequence similarity 185, member A [ Mus musculus (house mouse) ]

    Gene ID: 330050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam185aprovided by MGI
    Official Full Name
    family with sequence similarity 185, member Aprovided by MGI
    Primary source
    MGI:MGI:2140983
    See related
    Ensembl:ENSMUSG00000047221 AllianceGenome:MGI:2140983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631428I10
    Summary
    Orthologous to human FAM185A (family with sequence similarity 185 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 1.8), frontal lobe adult (RPKM 1.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam185a in Genome Data Viewer
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21629861..21693269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21424861..21488271)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-secretase activating protein Neighboring gene coiled-coil domain containing 146 Neighboring gene STARR-positive B cell enhancer ABC_E6308 Neighboring gene VISTA enhancer mm186 Neighboring gene predicted gene, 50626 Neighboring gene STARR-positive B cell enhancer ABC_E6309 Neighboring gene STARR-positive B cell enhancer ABC_E6310 Neighboring gene STARR-seq mESC enhancer starr_12565 Neighboring gene STARR-positive B cell enhancer ABC_E3562 Neighboring gene fibrinogen-like protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E152 Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene STARR-seq mESC enhancer starr_12566 Neighboring gene STARR-seq mESC enhancer starr_12567 Neighboring gene leucine rich repeat containing 17 Neighboring gene predicted gene 6543

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM185A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424684.1 → NP_001411613.1  protein FAM185A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157936, AC161484

    2. NM_177869.5 → NP_808537.2  protein FAM185A isoform 1

      See identical proteins and their annotated locations for NP_808537.2

      Status: VALIDATED

      Source sequence(s)
      AC157936
      Consensus CDS
      CCDS39022.1
      UniProtKB/Swiss-Prot
      Q7TPD2, Q8C6A4
      Related
      ENSMUSP00000058333.5, ENSMUST00000056045.5
      Conserved Domains (2) summary
      pfam13944
      Location:120 → 208
      Calycin_like; Calycin-like beta-barrel domain
      cl23960
      Location:130 → 302
      DUF2807; Putative auto-transporter adhesin, head GIN domain

    RNA

    1. NR_188850.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157936

    2. NR_188851.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157936

    3. NR_188852.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157936

    4. NR_188853.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC157936

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21629861..21693269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249773.2 → XP_011248075.1  protein FAM185A isoform X2

      Conserved Domains (1) summary
      cl23960
      Location:133 → 255
      DUF4097; Putative adhesin

    RNA

    1. XR_003955661.2 RNA Sequence

    2. XR_003955662.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPD2.1 GenPept UniProtKB/Swiss-Prot:Q7TPD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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