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    Pknox2 Pbx/knotted 1 homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 208076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pknox2provided by MGI
    Official Full Name
    Pbx/knotted 1 homeobox 2provided by MGI
    Primary source
    MGI:MGI:2445415
    See related
    Ensembl:ENSMUSG00000035934 AllianceGenome:MGI:2445415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prep2; D230005H23Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; actin filament binding activity; and actin monomer binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 26.9), cortex adult (RPKM 10.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pknox2 in Genome Data Viewer
    Location:
    9 A4; 9 20.7 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36802278..37058637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36890979..37147342, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA Neighboring gene predicted gene 27219 Neighboring gene STARR-seq mESC enhancer starr_23786 Neighboring gene fasciculation and elongation protein zeta 1 Neighboring gene STARR-seq mESC enhancer starr_23787 Neighboring gene predicted gene, 34652 Neighboring gene VISTA enhancer mm577 Neighboring gene predicted gene, 34538 Neighboring gene STARR-seq mESC enhancer starr_23793 Neighboring gene predicted gene, 48716 Neighboring gene STARR-positive B cell enhancer mm9_chr9:36984672-36984973 Neighboring gene STARR-positive B cell enhancer ABC_E249 Neighboring gene STARR-seq mESC enhancer starr_23796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:37038155-37038413 Neighboring gene transmembrane protein 218 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 2 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis. Miyake Y, et al. Biochem Biophys Res Commun, 2021 Sep 24. PMID 34311199
    2. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis. Chen L, et al. Signal Transduct Target Ther, 2024 Apr 22. PMID 38644381, Free PMC Article
    3. Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea. Trigila AP, et al. Mol Biol Evol, 2023 Jul 5. PMID 37247388, Free PMC Article
    4. Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export. Haller K, et al. J Biol Chem, 2004 Nov 19. PMID 15339927
    5. Prep2: cloning and expression of a new prep family member. Haller K, et al. Dev Dyn, 2002 Nov. PMID 12412021

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
      Title: PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis.
    2. Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.
      Title: Accelerated Evolution Analysis Uncovers PKNOX2 as a Key Transcription Factor in the Mammalian Cochlea.
    3. PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.
      Title: PKNOX2 regulates myofibroblast functions and tubular cell survival during kidney fibrosis.
    4. results indicated that Pknox2 misexpression affected mesenchymal condensation and early chondrogenic differentiation in the zeugopod skeletons of transgenic embryos
      Title: Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation.
    5. Prep2 functions to varying degrees in a broad array of tissues and developmental processes.
      Title: Prep2: cloning and expression of a new prep family member.
    6. transcriptional regulation by PREP2 is modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems
      Title: Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein PKNOX2
    Names
    PBX/knotted homeobox 2
    homeobox protein PREP-2
    homeodomain containing transcription factor PREP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029838.3 → NP_001025009.1  homeobox protein PKNOX2 isoform 1

      See identical proteins and their annotated locations for NP_001025009.1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      Consensus CDS
      CCDS22974.1
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Related
      ENSMUSP00000035806.6, ENSMUST00000039674.13
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    2. NM_001424685.1 → NP_001411614.1  homeobox protein PKNOX2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0

    3. NM_001424686.1 → NP_001411615.1  homeobox protein PKNOX2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0

    4. NM_001424687.1 → NP_001411616.1  homeobox protein PKNOX2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699

    5. NM_001424688.1 → NP_001411617.1  homeobox protein PKNOX2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699

    6. NM_001424689.1 → NP_001411618.1  homeobox protein PKNOX2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699

    7. NM_001424690.1 → NP_001411619.1  homeobox protein PKNOX2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699

    8. NM_148950.4 → NP_683752.2  homeobox protein PKNOX2 isoform 1

      See identical proteins and their annotated locations for NP_683752.2

      Status: VALIDATED

      Source sequence(s)
      AC164087, CT009699
      Consensus CDS
      CCDS22974.1
      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Related
      ENSMUSP00000135581.2, ENSMUST00000177218.8
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      36802278..37058637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154763.1 → XP_036010656.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    2. XM_006510126.5 → XP_006510189.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510189.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    3. XM_006510125.5 → XP_006510188.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510188.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    4. XM_036154762.1 → XP_036010655.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    5. XM_036154764.1 → XP_036010657.1  homeobox protein PKNOX2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    6. XM_006510127.5 → XP_006510190.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510190.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG

    7. XM_006510124.5 → XP_006510187.1  homeobox protein PKNOX2 isoform X1

      See identical proteins and their annotated locations for XP_006510187.1

      UniProtKB/Swiss-Prot
      Q8BG99, Q8R4B0
      Conserved Domains (3) summary
      pfam05920
      Location:306 → 345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:96 → 181
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
      NF033760
      Location:5 → 77
      gliding_GltG; adventurous gliding motility protein GltG
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG99.1 GenPept UniProtKB/Swiss-Prot:Q8BG99

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