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    Armcx2 armadillo repeat containing, X-linked 2 [ Mus musculus (house mouse) ]

    Gene ID: 67416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Armcx2provided by MGI
    Official Full Name
    armadillo repeat containing, X-linked 2provided by MGI
    Primary source
    MGI:MGI:1914666
    See related
    Ensembl:ENSMUSG00000033436 AllianceGenome:MGI:1914666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALEX2; 3230401N03Rik
    Summary
    Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including brain; future brain; liver; reproductive system; and trunk. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 29.0), CNS E14 (RPKM 27.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Armcx2 in Genome Data Viewer
    Location:
    X E3; X 56.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133704891..133709970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134804142..134809221, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene microRNA 7093 Neighboring gene armadillo repeat containing, X-linked 3 Neighboring gene STARR-seq mESC enhancer starr_47969 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene developmental pluripotency associated 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, et al. Dev Dyn, 2005 May. PMID 15759267
    2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
    3. A mammalian-specific Alex3/Gα(q) protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival. Izquierdo-Villalba I, et al. Sci Signal, 2024 Feb 6. PMID 38320000
    4. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. has a role in specification or development of the interstitial cell lineage in the developing testis
      Title: Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166397.1 → NP_001159869.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001159869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Related
      ENSMUSP00000108818.3, ENSMUST00000113193.9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    2. NM_001166398.1 → NP_001159870.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001159870.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two different segments in its 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK081299, AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Related
      ENSMUSP00000049147.5, ENSMUST00000035559.11
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    3. NM_026139.4 → NP_080415.3  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_080415.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK044926, AK053354, AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Related
      ENSMUSP00000127305.2, ENSMUST00000168264.2
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133704891..133709970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528602.2 → XP_006528665.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528665.1

      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    2. XM_006528600.2 → XP_006528663.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528663.1

      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    3. XM_036162079.1 → XP_036017972.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    4. XM_006528603.3 → XP_006528666.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528666.1

      UniProtKB/Swiss-Prot
      A2AKS5, Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A058.2 GenPept UniProtKB/Swiss-Prot:Q6A058

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