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    Zfp418 zinc finger protein 418 [ Mus musculus (house mouse) ]

    Gene ID: 232854, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp418provided by MGI
    Official Full Name
    zinc finger protein 418provided by MGI
    Primary source
    MGI:MGI:2444763
    See related
    Ensembl:ENSMUSG00000034538 AllianceGenome:MGI:2444763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZNF418; A230102I05Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in microautophagy and regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within cardiac muscle hypertrophy; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein phosphorylation. Is active in nucleus. Orthologous to human ZNF416 (zinc finger protein 416). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.0), CNS E14 (RPKM 1.0) and 25 other tissues See more
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    Genomic context

    See Zfp418 in Genome Data Viewer
    Location:
    7 A1; 7 4.16 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (7174352..7186559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (7171353..7183560)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18003 Neighboring gene zinc finger protein 773 Neighboring gene STARR-seq mESC enhancer starr_18004 Neighboring gene STARR-seq mESC enhancer starr_18005 Neighboring gene vomeronasal 2, receptor, pseudogene 35 Neighboring gene STARR-positive B cell enhancer ABC_E4895 Neighboring gene zinc finger protein 772 Neighboring gene vomeronasal 2, receptor 29 Neighboring gene zinc finger protein 772 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • MGC31575

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    is_active_in nucleus  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146179.2NP_666291.2  zinc finger protein 418

      See identical proteins and their annotated locations for NP_666291.2

      Status: VALIDATED

      Source sequence(s)
      AC150745, AK039147, BB671687
      Consensus CDS
      CCDS39756.1
      UniProtKB/Swiss-Prot
      Q8BFS8
      Related
      ENSMUSP00000057159.8, ENSMUST00000051435.8
      Conserved Domains (5) summary
      smart00349
      Location:2566
      KRAB; krueppel associated box
      COG5048
      Location:282639
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:566586
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2564
      KRAB; KRAB box
      pfam13465
      Location:606631
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      7174352..7186559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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