U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Med25 mediator complex subunit 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292889, updated on 27-Nov-2024

    Summary

    Official Symbol
    Med25provided by RGD
    Official Full Name
    mediator complex subunit 25provided by RGD
    Primary source
    RGD:1305137
    See related
    EnsemblRapid:ENSRNOG00000020363 AllianceGenome:RGD:1305137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305137
    Summary
    Predicted to enable nuclear retinoid X receptor binding activity and transcription coactivator binding activity. Predicted to be involved in negative regulation of fibroblast proliferation; positive regulation of mediator complex assembly; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 63.2), Adrenal (RPKM 55.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Med25 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104496447..104513061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95359961..95375827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100872240..100887864, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'-phosphatase Neighboring gene PTOV1, extended AT-hook containing adaptor protein Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor related protein complex 2 subunit alpha 1 Neighboring gene transfer RNA proline (anticodon AGG) 45 Neighboring gene testis-specific serine kinase substrate

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 25
    Names
    mediator of RNA polymerase II transcription, subunit 25 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170426.2NP_001163897.1  mediator of RNA polymerase II transcription subunit 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JAU0
      Related
      ENSRNOP00000094991.1, ENSRNOT00000117952.2
      Conserved Domains (4) summary
      pfam11232
      Location:401546
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:228384
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:664746
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:13225
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    2. NM_001415793.1NP_001402722.1  mediator of RNA polymerase II transcription subunit 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
    3. NM_001415794.1NP_001402723.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000027675.7, ENSRNOT00000027675.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104496447..104513061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284057.1XP_063140127.1  mediator of RNA polymerase II transcription subunit 25 isoform X2

    2. XM_006229010.5XP_006229072.3  mediator of RNA polymerase II transcription subunit 25 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Related
      ENSRNOP00000112460.1, ENSRNOT00000159201.1
      Conserved Domains (6) summary
      pfam09770
      Location:612743
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:462571
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:683739
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      pfam18658
      Location:754812
      zf-C2H2_12; Zinc-finger C2H2-type
    3. XM_006229007.5XP_006229069.3  mediator of RNA polymerase II transcription subunit 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJG1, A0A8I6B1T5
      Related
      ENSRNOP00000093019.1, ENSRNOT00000105598.2
      Conserved Domains (6) summary
      pfam09770
      Location:648779
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:462607
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:719775
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
      pfam18658
      Location:790848
      zf-C2H2_12; Zinc-finger C2H2-type
    4. XM_006229013.3XP_006229075.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      UniProtKB/TrEMBL
      D3ZJW8
      Conserved Domains (6) summary
      pfam09770
      Location:484615
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:626684
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. XM_063284073.1XP_063140143.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

    6. XM_039104904.2XP_038960832.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

      UniProtKB/TrEMBL
      D3ZJW8
      Conserved Domains (6) summary
      pfam09770
      Location:484615
      PAT1; Topoisomerase II-associated protein PAT1
      pfam11232
      Location:298443
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:125281
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:555611
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam18658
      Location:626684
      zf-C2H2_12; Zinc-finger C2H2-type
      cl00057
      Location:1123
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    7. XM_063284064.1XP_063140134.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

    8. XM_039104896.2XP_038960824.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:461606
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289444
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:694782
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    9. XM_006229011.5XP_006229073.3  mediator of RNA polymerase II transcription subunit 25 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:461606
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289444
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:718806
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    10. XM_063284065.1XP_063140135.1  mediator of RNA polymerase II transcription subunit 25 isoform X8

    11. XM_006229012.5XP_006229074.3  mediator of RNA polymerase II transcription subunit 25 isoform X5

      UniProtKB/TrEMBL
      A0A8I6B1T5
      Conserved Domains (4) summary
      pfam11232
      Location:462607
      Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
      pfam11235
      Location:289445
      Med25_SD1; Mediator complex subunit 25 synapsin 1
      pfam11244
      Location:695783
      Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
      pfam11265
      Location:73287
      Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A
    12. XM_063284077.1XP_063140147.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

    RNA

    1. XR_010064657.1 RNA Sequence

    2. XR_010064656.1 RNA Sequence