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    Cenpv centromere protein V [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenpvprovided by RGD
    Official Full Name
    centromere protein Vprovided by RGD
    Primary source
    RGD:1565681
    See related
    EnsemblRapid:ENSRNOG00000003086 AllianceGenome:RGD:1565681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prr6; RGD1565681
    Summary
    Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Predicted to be involved in several processes, including centromere complex assembly; pericentric heterochromatin formation; and positive regulation of cytokinesis. Predicted to act upstream of or within ameboidal-type cell migration. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nucleus. Predicted to be active in kinetochore; nucleus; and spindle midzone. Orthologous to several human genes including CENPV (centromere protein V). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 138.4), Testes (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpv in Genome Data Viewer
    Location:
    10q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47713778..47746800, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47214479..47228552, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48846513..48861893, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene transmembrane p24 trafficking protein 4, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene ubiquitin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. Tadeu AM, et al. EMBO J, 2008 Oct 8. PMID 18772885, Free PMC Article
    2. Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction. Honda Z, et al. Genes Cells, 2009 Dec. PMID 19930468
    3. Proteomic analysis of the mammalian nuclear pore complex. Cronshaw JM, et al. J Cell Biol, 2002 Sep 2. PMID 12196509, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbon-sulfur lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ameboidal-type cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centromere complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pericentric heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pericentric heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein V
    Names
    proline rich 6
    proline-rich polypeptide 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398871.1 → NP_001385800.1  centromere protein V

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A9A3
      Related
      ENSRNOP00000004127.8, ENSRNOT00000004127.9
      Conserved Domains (1) summary
      COG3791
      Location:122 → 218
      COG3791; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      47713778..47746800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269676.1 → XP_063125746.1  centromere protein V isoform X3

    2. XM_063269675.1 → XP_063125745.1  centromere protein V isoform X2

    3. XM_039087273.2 → XP_038943201.1  centromere protein V isoform X1

      Conserved Domains (1) summary
      cl01553
      Location:122 → 156
      GFA; Glutathione-dependent formaldehyde-activating enzyme

    RNA

    1. XR_005490266.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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