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    Tpst1 tyrosylprotein sulfotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288617, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpst1provided by RGD
    Official Full Name
    tyrosylprotein sulfotransferase 1provided by RGD
    Primary source
    RGD:1308473
    See related
    EnsemblRapid:ENSRNOG00000000900 AllianceGenome:RGD:1308473
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in post-translational protein modification. Predicted to act upstream of or within peptidyl-tyrosine sulfation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 120.7), Testes (RPKM 106.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tpst1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32180688..32247478, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26544536..26605706, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30045753..30112377, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RAB guanine nucleotide exchange factor 1 Neighboring gene potassium channel tetramerization domain containing 7 Neighboring gene CGRP receptor component Neighboring gene small nucleolar RNA SNORA17 Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC125193

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-tyrosine sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-tyrosine sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-tyrosine sulfation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine sulfation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    NP_001011903.2
    XP_006249296.1
    XP_063127234.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011903.2NP_001011903.2  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_001011903.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105826
      UniProtKB/Swiss-Prot
      Q3KR92
      UniProtKB/TrEMBL
      A6J0M9, Q6AYS9
      Related
      ENSRNOP00000060104.3, ENSRNOT00000065868.3
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32180688..32247478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271164.1XP_063127234.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3KR92
      UniProtKB/TrEMBL
      A6J0M9, Q6AYS9
    2. XM_006249234.4XP_006249296.1  protein-tyrosine sulfotransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QSG0, Q6AYS9
      Related
      ENSRNOP00000001200.5, ENSRNOT00000001200.7
      Conserved Domains (1) summary
      pfam13469
      Location:72261
      Sulfotransfer_3; Sulfotransferase family