Ncor2 nuclear receptor co-repressor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncor2provided by RGD
Official Full Name: nuclear receptor co-repressor 2provided by RGD
Primary source: RGD:1310293
See related: EnsemblRapid:ENSRNOG00000001004 AllianceGenome:RGD:1310293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity; nuclear glucocorticoid receptor binding activity; and nuclear retinoid X receptor binding activity. Involved in several processes, including estrous cycle; lactation; and response to estradiol. Located in chromatin. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 91.5), Spleen (RPKM 47.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 51

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37127736..37289612)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (31466418..31628319)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (36871917..37033701)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE098792 (e-PCR)
- UniSTS:245296

D1S3692 (e-PCR)
- UniSTS:474270

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermis development	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in random inactivation of X chromosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of ketone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type I pneumocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of white fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within white fat cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor corepressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108334.1 → NP_001101804.1 nuclear receptor corepressor 2

See identical proteins and their annotated locations for NP_001101804.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/TrEMBL

A6J0X3, D3ZXN9

Conserved Domains (4) summary

smart00717
Location:610 → 655

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:610 → 653

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:142 → 228

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

37127736..37289612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249305.5 → XP_006249367.1 nuclear receptor corepressor 2 isoform X24

UniProtKB/TrEMBL

D3ZXN9

Conserved Domains (6) summary

PHA03247
Location:1917 → 2321

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:156 → 411

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG5259
Location:539 → 649

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

pfam00249
Location:614 → 657

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:141 → 229

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_006249320.5 → XP_006249382.1 nuclear receptor corepressor 2 isoform X42

UniProtKB/TrEMBL

D3ZXN9

Conserved Domains (4) summary

smart00717
Location:614 → 659

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

pfam00249
Location:614 → 657

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:142 → 228

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_017598397.3 → XP_017453886.1 nuclear receptor corepressor 2 isoform X44

UniProtKB/TrEMBL

A0A0G2JU91, D3ZXN9

Related

ENSRNOP00000001334.5, ENSRNOT00000001334.8
XM_017598398.3 → XP_017453887.1 nuclear receptor corepressor 2 isoform X45

UniProtKB/TrEMBL

D3ZXN9

Related

ENSRNOP00000069011.3, ENSRNOT00000084236.3
XM_063271518.1 → XP_063127588.1 nuclear receptor corepressor 2 isoform X25
XM_039089593.2 → XP_038945521.1 nuclear receptor corepressor 2 isoform X43

UniProtKB/TrEMBL

D3ZXN9

Conserved Domains (6) summary

PHA03247
Location:1757 → 2258

PHA03247; large tegument protein UL36; Provisional

COG5259
Location:538 → 648

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

TIGR02169
Location:159 → 404

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam00249
Location:613 → 656

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:141 → 229

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:431 → 474

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_039089594.2 → XP_038945522.1 nuclear receptor corepressor 2 isoform X46

UniProtKB/TrEMBL

A0A8I6AN60

Conserved Domains (6) summary

PHA03247
Location:1757 → 2258

PHA03247; large tegument protein UL36; Provisional

COG5259
Location:538 → 648

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

TIGR02169
Location:159 → 404

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam00249
Location:613 → 656

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:141 → 229

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:431 → 474

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_063271525.1 → XP_063127595.1 nuclear receptor corepressor 2 isoform X33
XM_063271499.1 → XP_063127569.1 nuclear receptor corepressor 2 isoform X6
XM_063271502.1 → XP_063127572.1 nuclear receptor corepressor 2 isoform X9
XM_063271507.1 → XP_063127577.1 nuclear receptor corepressor 2 isoform X14
XM_063271513.1 → XP_063127583.1 nuclear receptor corepressor 2 isoform X20
XM_063271508.1 → XP_063127578.1 nuclear receptor corepressor 2 isoform X15
XM_063271519.1 → XP_063127589.1 nuclear receptor corepressor 2 isoform X26
XM_063271506.1 → XP_063127576.1 nuclear receptor corepressor 2 isoform X13
XM_063271514.1 → XP_063127584.1 nuclear receptor corepressor 2 isoform X21
XM_063271521.1 → XP_063127591.1 nuclear receptor corepressor 2 isoform X29
XM_063271517.1 → XP_063127587.1 nuclear receptor corepressor 2 isoform X23
XM_063271523.1 → XP_063127593.1 nuclear receptor corepressor 2 isoform X31
XM_063271524.1 → XP_063127594.1 nuclear receptor corepressor 2 isoform X32
XM_063271501.1 → XP_063127571.1 nuclear receptor corepressor 2 isoform X8
XM_063271515.1 → XP_063127585.1 nuclear receptor corepressor 2 isoform X22
XM_063271522.1 → XP_063127592.1 nuclear receptor corepressor 2 isoform X30
XM_063271498.1 → XP_063127568.1 nuclear receptor corepressor 2 isoform X3
XM_063271503.1 → XP_063127573.1 nuclear receptor corepressor 2 isoform X10
XM_063271509.1 → XP_063127579.1 nuclear receptor corepressor 2 isoform X16
XM_063271504.1 → XP_063127574.1 nuclear receptor corepressor 2 isoform X11
XM_063271511.1 → XP_063127581.1 nuclear receptor corepressor 2 isoform X18
XM_017598392.3 → XP_017453881.1 nuclear receptor corepressor 2 isoform X4

UniProtKB/TrEMBL

A0A8I6GHM0
XM_063271512.1 → XP_063127582.1 nuclear receptor corepressor 2 isoform X19
XM_017598396.3 → XP_017453885.1 nuclear receptor corepressor 2 isoform X28

UniProtKB/TrEMBL

A0A8I6GHM0
XM_039089589.2 → XP_038945517.1 nuclear receptor corepressor 2 isoform X5

UniProtKB/TrEMBL

A0A8I6GHM0

Conserved Domains (6) summary

PHA03247
Location:1741 → 2145

PHA03247; large tegument protein UL36; Provisional

COG5259
Location:364 → 474

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

TIGR02169
Location:5 → 283

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam00249
Location:439 → 482

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:1 → 54

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:257 → 300

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_017598391.3 → XP_017453880.1 nuclear receptor corepressor 2 isoform X1

UniProtKB/TrEMBL

A0A8I6GHM0
XM_063271510.1 → XP_063127580.1 nuclear receptor corepressor 2 isoform X17

Related

ENSRNOP00000089758.1, ENSRNOT00000104620.2
XM_063271520.1 → XP_063127590.1 nuclear receptor corepressor 2 isoform X27
XM_063271505.1 → XP_063127575.1 nuclear receptor corepressor 2 isoform X12
XM_063271500.1 → XP_063127570.1 nuclear receptor corepressor 2 isoform X7
XM_063271497.1 → XP_063127567.1 nuclear receptor corepressor 2 isoform X2
XM_063271527.1 → XP_063127597.1 nuclear receptor corepressor 2 isoform X35
XM_063271528.1 → XP_063127598.1 nuclear receptor corepressor 2 isoform X36
XM_039089591.2 → XP_038945519.1 nuclear receptor corepressor 2 isoform X24

UniProtKB/TrEMBL

D3ZXN9

Conserved Domains (6) summary

PHA03247
Location:1917 → 2321

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:156 → 411

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG5259
Location:539 → 649

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

pfam00249
Location:614 → 657

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:141 → 229

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_017598394.3 → XP_017453883.1 nuclear receptor corepressor 2 isoform X24

UniProtKB/TrEMBL

D3ZXN9

Conserved Domains (6) summary

PHA03247
Location:1917 → 2321

PHA03247; large tegument protein UL36; Provisional

COG0419
Location:156 → 411

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG5259
Location:539 → 649

RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]

pfam00249
Location:614 → 657

Myb_DNA-binding; Myb-like DNA-binding domain

pfam15784
Location:141 → 229

GPS2_interact; G-protein pathway suppressor 2-interacting domain

cl21498
Location:432 → 475

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_063271526.1 → XP_063127596.1 nuclear receptor corepressor 2 isoform X34
XM_039089592.2 → XP_038945520.1 nuclear receptor corepressor 2 isoform X37

UniProtKB/TrEMBL

A6J0X4

Conserved Domains (2) summary

PHA03247
Location:1307 → 1711

PHA03247; large tegument protein UL36; Provisional

pfam00249
Location:19 → 47

Myb_DNA-binding; Myb-like DNA-binding domain
XM_063271529.1 → XP_063127599.1 nuclear receptor corepressor 2 isoform X38
XM_063271530.1 → XP_063127600.1 nuclear receptor corepressor 2 isoform X39
XM_063271531.1 → XP_063127601.1 nuclear receptor corepressor 2 isoform X40
XM_063271532.1 → XP_063127602.1 nuclear receptor corepressor 2 isoform X41