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    Grk4 G protein-coupled receptor kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grk4provided by RGD
    Official Full Name
    G protein-coupled receptor kinase 4provided by RGD
    Primary source
    RGD:61858
    See related
    EnsemblRapid:ENSRNOG00000011847 AllianceGenome:RGD:61858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gprk2l
    Summary
    Enables rhodopsin kinase activity. Involved in G protein-coupled receptor internalization and protein phosphorylation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 90.1), Lung (RPKM 33.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grk4 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (80230699..80305292, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75998554..76080808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (81261708..81339516, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene huntingtin Neighboring gene uncharacterized LOC134481857 Neighboring gene NOP14 nucleolar protein Neighboring gene major facilitator superfamily domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells. Fraga S, et al. Am J Physiol Regul Integr Comp Physiol, 2004 Oct. PMID 15166006
    2. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1. Sallese M, et al. FASEB J, 2000 Dec. PMID 11099476
    3. Rat G protein-coupled receptor kinase GRK4: identification, functional expression, and differential tissue distribution of two splice variants. Virlon B, et al. Endocrinology, 1998 Jun. PMID 9607785
    4. Role of GRK4 in the regulation of the renal ETB receptor in hypertension. Yang Y, et al. FASEB J, 2020 Sep. PMID 32687659, Free PMC Article
    5. Buffalo colostrum β-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase. Chougule RA, et al. Appl Biochem Biotechnol, 2013 Sep. PMID 23839509

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
      Title: GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
    2. Role of GRK4 in the regulation of the renal ETB receptor in hypertension.
      Title: Role of GRK4 in the regulation of the renal ETB receptor in hypertension.
    3. Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase
      Title: Buffalo colostrum β-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase.
    4. Crucial role of renal GRK4 in D1 receptor control of sodium excretion and blood pressure in genetic hypertension.
      Title: Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression.
    5. selective renal reduction of GRK4 expression by infusion of GRK4 antisense oligonucleotide increases sodium excretion, attenuates the increase in arterial BP with age, and modestly decreases protein excretion in SHR, but not in WKY.
      Title: Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rhodopsin kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in desensitization of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 4
    Names
    G protein-coupled receptor kinase 2, groucho gene related
    g protein-coupled receptor kinase GRK4
    NP_075217.1
    XP_006251421.1
    XP_006251422.1
    XP_017454835.1
    XP_017454836.1
    XP_038948280.1
    XP_038948284.1
    XP_038948285.1
    XP_038948288.1
    XP_063129586.1
    XP_063129587.1
    XP_063129588.1
    XP_063129589.1
    XP_063129590.1
    XP_063129591.1
    XP_063129592.1
    XP_063129593.1
    XP_063129594.1
    XP_063129595.1
    XP_063129596.1
    XP_063129597.1
    XP_063129598.1
    XP_063129599.1
    XP_063129600.1
    XP_063129601.1
    XP_063129602.1
    XP_063129604.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428989.1 → NP_001415918.1  G protein-coupled receptor kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A4S4

    2. NM_001428990.1 → NP_001415919.1  G protein-coupled receptor kinase 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A4S4

    3. NM_001428991.1 → NP_001415920.1  G protein-coupled receptor kinase 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZVP3, A0A8I6A4S4

    4. NM_022928.2 → NP_075217.1  G protein-coupled receptor kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_075217.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P70507, P70508
      UniProtKB/TrEMBL
      A0A8I6A4S4, A6IK17
      Related
      ENSRNOP00000015894.2, ENSRNOT00000015894.6
      Conserved Domains (3) summary
      smart00220
      Location:186 → 448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05605
      Location:185 → 469
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      80230699..80305292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251359.4 → XP_006251421.1  G protein-coupled receptor kinase 4 isoform X7

      Conserved Domains (3) summary
      smart00220
      Location:155 → 417
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05605
      Location:154 → 438
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 145
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_039092352.2 → XP_038948280.1  G protein-coupled receptor kinase 4 isoform X6

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 439
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006251360.4 → XP_006251422.1  G protein-coupled receptor kinase 4 isoform X9

      Conserved Domains (3) summary
      smart00220
      Location:186 → 448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05605
      Location:185 → 468
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_017599347.3 → XP_017454836.1  G protein-coupled receptor kinase 4 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A4S4

    5. XM_017599346.3 → XP_017454835.1  G protein-coupled receptor kinase 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A4S4

    6. XM_063273524.1 → XP_063129594.1  G protein-coupled receptor kinase 4 isoform X13

    7. XM_063273523.1 → XP_063129593.1  G protein-coupled receptor kinase 4 isoform X12

    8. XM_063273525.1 → XP_063129595.1  G protein-coupled receptor kinase 4 isoform X14

    9. XM_063273534.1 → XP_063129604.1  G protein-coupled receptor kinase 4 isoform X23

    10. XM_063273520.1 → XP_063129590.1  G protein-coupled receptor kinase 4 isoform X10

    11. XM_063273518.1 → XP_063129588.1  G protein-coupled receptor kinase 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A4S4
      Related
      ENSRNOP00000088283.2, ENSRNOT00000094171.2

    12. XM_063273519.1 → XP_063129589.1  G protein-coupled receptor kinase 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A4S4

    13. XM_063273517.1 → XP_063129587.1  G protein-coupled receptor kinase 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4S4
      Related
      ENSRNOP00000101234.1, ENSRNOT00000168890.1

    14. XM_063273516.1 → XP_063129586.1  G protein-coupled receptor kinase 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4S4

    15. XM_063273522.1 → XP_063129592.1  G protein-coupled receptor kinase 4 isoform X11

    16. XM_063273521.1 → XP_063129591.1  G protein-coupled receptor kinase 4 isoform X11

    17. XM_063273531.1 → XP_063129601.1  G protein-coupled receptor kinase 4 isoform X15

    18. XM_063273526.1 → XP_063129596.1  G protein-coupled receptor kinase 4 isoform X15

    19. XM_063273530.1 → XP_063129600.1  G protein-coupled receptor kinase 4 isoform X20

    20. XM_063273529.1 → XP_063129599.1  G protein-coupled receptor kinase 4 isoform X19

    21. XM_063273528.1 → XP_063129598.1  G protein-coupled receptor kinase 4 isoform X16

    22. XM_063273527.1 → XP_063129597.1  G protein-coupled receptor kinase 4 isoform X16

    23. XM_039092360.2 → XP_038948288.1  G protein-coupled receptor kinase 4 isoform X22

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 311
      PKc_like; Protein Kinases, catalytic domain

    24. XM_039092356.2 → XP_038948284.1  G protein-coupled receptor kinase 4 isoform X17

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 310
      PKc_like; Protein Kinases, catalytic domain

    25. XM_063273532.1 → XP_063129602.1  G protein-coupled receptor kinase 4 isoform X21

    26. XM_039092357.2 → XP_038948285.1  G protein-coupled receptor kinase 4 isoform X18

      Conserved Domains (2) summary
      cl02565
      Location:51 → 183
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:185 → 312
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010057407.1 RNA Sequence

    2. XR_010057403.1 RNA Sequence

    3. XR_010057402.1 RNA Sequence

    4. XR_005493008.2 RNA Sequence

    5. XR_010057406.1 RNA Sequence

    6. XR_010057408.1 RNA Sequence

    7. XR_010057405.1 RNA Sequence

    8. XR_010057404.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70507.1 GenPept UniProtKB/Swiss-Prot:P70507

    Gene LinkOut

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