Pcm1 pericentriolar material 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcm1provided by RGD
Official Full Name: pericentriolar material 1provided by RGD
Primary source: RGD:620901
See related: EnsemblRapid:ENSRNOG00000010155 AllianceGenome:RGD:620901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity. Involved in protein localization to centrosome. Predicted to be located in several cellular components, including ciliary transition zone; microtubule organizing center; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in centriolar satellite and ciliary basal body. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 287.9), Testes (RPKM 285.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (57711833..57808842, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51008315..51105261, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54040721..54137675, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in interkinetic nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in intraciliary transport involved in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring at centrosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein localization to centrosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization to centriolar satellite	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
NOT located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pericentriolar material 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031076.1 → NP_112338.1 pericentriolar material 1 protein

See identical proteins and their annotated locations for NP_112338.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I5ZUW5, A6JPT8, G3V7E6

Related

ENSRNOP00000014202.4, ENSRNOT00000014202.8

Conserved Domains (1) summary

pfam15717
Location:1369 → 2000

PCM1_C; Pericentriolar material 1 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

57711833..57808842 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771284.4 → XP_008769506.1 pericentriolar material 1 protein isoform X1

See identical proteins and their annotated locations for XP_008769506.1

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (2) summary

pfam15717
Location:1471 → 2102

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_006253188.5 → XP_006253250.1 pericentriolar material 1 protein isoform X6

See identical proteins and their annotated locations for XP_006253250.1

UniProtKB/TrEMBL

A0A8I5ZUW5, A0A8I6A6S1, A6JPT9

Related

ENSRNOP00000089217.1, ENSRNOT00000109286.2

Conserved Domains (2) summary

pfam15717
Location:1408 → 2039

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:782 → 866

UPF0047; uncharacterized protein family UPF0047
XM_006253183.5 → XP_006253245.1 pericentriolar material 1 protein isoform X1

See identical proteins and their annotated locations for XP_006253245.1

UniProtKB/TrEMBL

A0A8I5ZUW5

Related

ENSRNOP00000082952.2, ENSRNOT00000106424.2

Conserved Domains (2) summary

pfam15717
Location:1471 → 2102

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_063275772.1 → XP_063131842.1 pericentriolar material 1 protein isoform X13

UniProtKB/TrEMBL

A0A8I5Y9X1, A0A8I5ZUW5

Related

ENSRNOP00000078093.1, ENSRNOT00000104140.2
XM_063275770.1 → XP_063131840.1 pericentriolar material 1 protein isoform X11

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_017600257.3 → XP_017455746.1 pericentriolar material 1 protein isoform X10

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_039094854.2 → XP_038950782.1 pericentriolar material 1 protein isoform X2

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (1) summary

pfam15717
Location:1432 → 2063

PCM1_C; Pericentriolar material 1 C-terminus
XM_063275771.1 → XP_063131841.1 pericentriolar material 1 protein isoform X12

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_063275769.1 → XP_063131839.1 pericentriolar material 1 protein isoform X9

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_039094856.2 → XP_038950784.1 pericentriolar material 1 protein isoform X8

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (1) summary

pfam15717
Location:1353 → 1984

PCM1_C; Pericentriolar material 1 C-terminus
XM_006253187.5 → XP_006253249.1 pericentriolar material 1 protein isoform X5

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (2) summary

pfam15717
Location:1413 → 2044

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:787 → 871

UPF0047; uncharacterized protein family UPF0047
XM_006253186.5 → XP_006253248.1 pericentriolar material 1 protein isoform X4

UniProtKB/TrEMBL

A0A0G2K0X1, A0A8I5ZUW5

Related

ENSRNOP00000071613.2, ENSRNOT00000085435.3

Conserved Domains (3) summary

pfam02463
Location:226 → 987

SMC_N; RecF/RecN/SMC N terminal domain

pfam15717
Location:1416 → 2047

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_006253185.5 → XP_006253247.1 pericentriolar material 1 protein isoform X3

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (2) summary

pfam15717
Location:1471 → 2049

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_006253184.5 → XP_006253246.1 pericentriolar material 1 protein isoform X1

See identical proteins and their annotated locations for XP_006253246.1

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (2) summary

pfam15717
Location:1471 → 2102

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_063275766.1 → XP_063131836.1 pericentriolar material 1 protein isoform X7

UniProtKB/TrEMBL

A0A8I5ZUW5, A6JPT8, G3V7E6
XM_063275765.1 → XP_063131835.1 pericentriolar material 1 protein isoform X6

UniProtKB/TrEMBL

A0A8I5ZUW5, A0A8I6A6S1, A6JPT9
XM_063275768.1 → XP_063131838.1 pericentriolar material 1 protein isoform X7

UniProtKB/TrEMBL

A0A8I5ZUW5, A6JPT8, G3V7E6
XM_063275762.1 → XP_063131832.1 pericentriolar material 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_008771285.4 → XP_008769507.1 pericentriolar material 1 protein isoform X1

See identical proteins and their annotated locations for XP_008769507.1

UniProtKB/TrEMBL

A0A8I5ZUW5

Conserved Domains (2) summary

pfam15717
Location:1471 → 2102

PCM1_C; Pericentriolar material 1 C terminus

cl00439
Location:845 → 929

UPF0047; uncharacterized protein family UPF0047
XM_063275767.1 → XP_063131837.1 pericentriolar material 1 protein isoform X7

UniProtKB/TrEMBL

A0A8I5ZUW5, A6JPT8, G3V7E6
XM_063275764.1 → XP_063131834.1 pericentriolar material 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_063275763.1 → XP_063131833.1 pericentriolar material 1 protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZUW5
XM_063275773.1 → XP_063131843.1 pericentriolar material 1 protein isoform X14