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    Palldl1 palladin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364558, updated on 9-Dec-2024

    Summary

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    Symbol
    Palldl1provided by RGD
    Full Name
    palladin-like 1provided by RGD
    Primary source
    RGD:1359390
    See related
    EnsemblRapid:ENSRNOG00000082157 AllianceGenome:RGD:1359390
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Palld
    Summary
    Predicted to be involved in several processes, including actin cytoskeleton organization; cell migration; and nervous system development. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 452.0) and Muscle (RPKM 395.5) See more
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    Genomic context

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    See Palldl1 in Genome Data Viewer
    Location:
    16p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (32985252..33154619)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (27981315..28143129)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31349140..31390340)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene probable ATP-dependent RNA helicase DDX60 Neighboring gene uncharacterized LOC134482493 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC134482494 Neighboring gene uncharacterized LOC120097508

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium. Nicholson L, et al. Reprod Fertil Dev, 2018 Oct. PMID 29739492
    2. CLP36 interacts with palladin in dorsal root ganglion neurons. Hasegawa T, et al. Neurosci Lett, 2010 May 31. PMID 20381583
    3. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, et al. Cancer Biol Ther, 2007 Mar. PMID 17404500, Free PMC Article
    4. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, et al. Mol Cell Neurosci, 2003 Aug. PMID 12932445
    5. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. Pogue-Geile KL, et al. PLoS Med, 2006 Dec. PMID 17194196, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two palladin isoforms, 140 kDa and 90 kDa, were analysed, with the migration-associated 140-kDa isoform increasing significantly in rat uterus at the time of implantation when compared with the time of fertilisation.
      Title: Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
    2. Palladin is an actin filament regulator at the ectoplasmic specialization.
      Title: Palladin is a regulator of actin filament bundles at the ectoplasmic specialization in adult rat testes.
    3. Actin associated protein palladin is important for the early smooth muscle cell differentiation.
      Title: The actin associated protein palladin is important for the early smooth muscle cell differentiation.
    4. CLP36 may interact with palladin to influence neurite outgrowth during sciatic nerve regeneration.
      Title: CLP36 interacts with palladin in dorsal root ganglion neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palladin
    Names
    palladin, cytoskeletal associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      32985252..33154619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095179.2 → XP_038951107.2  palladin isoform X3

      UniProtKB/TrEMBL
      Q5M7W2

    2. XM_063275968.1 → XP_063132038.1  palladin isoform X3

      UniProtKB/TrEMBL
      Q5M7W2

    3. XM_039095178.2 → XP_038951106.2  palladin isoform X2

      UniProtKB/TrEMBL
      Q5M7W2

    4. XM_039095177.2 → XP_038951105.2  palladin isoform X1

      UniProtKB/TrEMBL
      Q5M7W2

    5. XM_039095181.2 → XP_038951109.2  palladin isoform X4

      UniProtKB/TrEMBL
      Q5M7W2
      Related
      ENSRNOP00000084755.2, ENSRNOT00000064850.5

    6. XM_063275969.1 → XP_063132039.1  palladin isoform X5

      UniProtKB/TrEMBL
      Q5M7W2

    7. XM_039095182.2 → XP_038951110.2  palladin isoform X4

      UniProtKB/TrEMBL
      Q5M7W2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014237.1: Suppressed sequence

      Description
      NM_001014237.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PALLD (GeneID:23022).
    Nucleotide Protein Strain
    Heading Accession and Version

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