Cenpt centromere protein T [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenptprovided by RGD
Official Full Name: centromere protein Tprovided by RGD
Primary source: RGD:1309383
See related: EnsemblRapid:ENSRNOG00000024178 AllianceGenome:RGD:1309383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309383
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Predicted to be located in kinetochore and nuclear body. Predicted to be part of inner kinetochore. Orthologous to human CENPT (centromere protein T). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 97.0), Spleen (RPKM 73.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50644548..50651048, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33734684..33741159, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37813284..37819782, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in kinetochore assembly	IEA Inferred from Electronic Annotation more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
part_of inner kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: centromere protein T

Names: CENP-T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024257.1 → NP_001019428.1 centromere protein T

See identical proteins and their annotated locations for NP_001019428.1

Status: PROVISIONAL

Source sequence(s)

BC093396

UniProtKB/Swiss-Prot

Q561R1

UniProtKB/TrEMBL

A0A8I6GKT8

Related

ENSRNOP00000029297.3, ENSRNOT00000036702.6

Conserved Domains (2) summary

pfam15511
Location:407 → 510

CENP-T_C; Centromere kinetochore component CENP-T histone fold

pfam16171
Location:1 → 375

CENP-T_N; Centromere kinetochore component CENP-T N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50644548..50651048 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278032.1 → XP_063134102.1 centromere protein T isoform X5

UniProtKB/TrEMBL

A6IYS7
XM_063278030.1 → XP_063134100.1 centromere protein T isoform X2

UniProtKB/TrEMBL

A0A8I6GKT8
XM_039097738.2 → XP_038953666.1 centromere protein T isoform X1

UniProtKB/TrEMBL

A0A8I6GKT8

Conserved Domains (2) summary

pfam15511
Location:483 → 586

CENP-T_C; Centromere kinetochore component CENP-T histone fold

pfam16171
Location:1 → 375

CENP-T_N; Centromere kinetochore component CENP-T N-terminus
XM_063278031.1 → XP_063134101.1 centromere protein T isoform X3

UniProtKB/TrEMBL

A0A8I6GKT8
XM_039097740.2 → XP_038953668.1 centromere protein T isoform X4

Conserved Domains (2) summary

pfam15511
Location:379 → 482

CENP-T_C; Centromere kinetochore component CENP-T histone fold

pfam16171
Location:1 → 271

CENP-T_N; Centromere kinetochore component CENP-T N-terminus
XM_039097739.2 → XP_038953667.1 centromere protein T isoform X4

Conserved Domains (2) summary

pfam15511
Location:379 → 482

CENP-T_C; Centromere kinetochore component CENP-T histone fold

pfam16171
Location:1 → 271

CENP-T_N; Centromere kinetochore component CENP-T N-terminus
XM_063278033.1 → XP_063134103.1 centromere protein T isoform X6